A new series of polyvalent drugs obtained by joining edaravone with NO-donor moieties is described. All compounds display high antioxidant power together with NO-dependent vasodilator properties. The analysis of a number of molecular descriptors shows that the antioxidant activity, which is tightly linked to the presence of the edaravone substructure, is principally modulated by lipophilicity. These products are potentially useful in the treatment of cardiovascular disorders in which EDRF deficiency and ROS excess are involved.

Edaravone derivatives containing NO-donor functions

CHEGAEV, Konstantin;CENA, Clara;GIORGIS, Marta;ROLANDO, Barbara;TOSCO, Paolo;BERTINARIA, Massimo;FRUTTERO, Roberta;GASCO, Alberto
2009

Abstract

A new series of polyvalent drugs obtained by joining edaravone with NO-donor moieties is described. All compounds display high antioxidant power together with NO-dependent vasodilator properties. The analysis of a number of molecular descriptors shows that the antioxidant activity, which is tightly linked to the presence of the edaravone substructure, is principally modulated by lipophilicity. These products are potentially useful in the treatment of cardiovascular disorders in which EDRF deficiency and ROS excess are involved.
52
2
574
578
http://pubs.acs.org/journal/jmcmar
Edaravone (MCI-186); multitarget drugs; NO-donors; NO-donor edaravone derivatives; antioxidants
Konstantin Chegaev; Clara Cena; Marta Giorgis; Barbara Rolando; Paolo Tosco; Massimo Bertinaria; Roberto Fruttero; Pier-Alain Carrupt; Alberto Gasco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/55707
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