Pure and modified silica materials were prepared by the sol-gel process and used as carrier for the controlled release of ibuprofen. A one-step synthesis was carried out for the preparation of the silica-drug composites and the sol-gel method was improved by using the ultrasounds in order to replace of acid or basic catalysts. It was found that the presence of methyl groups on the silica surface influences the drug delivery rate leading to a high degree of control of the desorption process.
One-step synthesis of silica gel used in the controlled release of drug
CERRATO, Giuseppina
2008-01-01
Abstract
Pure and modified silica materials were prepared by the sol-gel process and used as carrier for the controlled release of ibuprofen. A one-step synthesis was carried out for the preparation of the silica-drug composites and the sol-gel method was improved by using the ultrasounds in order to replace of acid or basic catalysts. It was found that the presence of methyl groups on the silica surface influences the drug delivery rate leading to a high degree of control of the desorption process.
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