Synthesis, structural characterization, and acid dissociation constants (pKa) of a series of methyl- and phenyl-substituted furoxansulfonic acids and related sulfonamide derivatives, as well as their furazan analogues are described. The ability of furoxans to dilate rat aorta strips precontracted with phenylephrine is reported as an example of their NO-dependent pharmacological properties.
Unsymmetrically Substituted Furoxans. Part 19. Methyl and Phenylfuroxansulfonic Acids and Related Sulfonamides
CHEGAEV, Konstantin;ROLANDO, Barbara;GUGLIELMO, Stefano;FRUTTERO, Roberta;GASCO, Alberto
2009-01-01
Abstract
Synthesis, structural characterization, and acid dissociation constants (pKa) of a series of methyl- and phenyl-substituted furoxansulfonic acids and related sulfonamide derivatives, as well as their furazan analogues are described. The ability of furoxans to dilate rat aorta strips precontracted with phenylephrine is reported as an example of their NO-dependent pharmacological properties.
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