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EnglishSolid lipid nanoparticles (SLN) made of different triglycerides (TG) in the presence and in the absence of various modified alpha- and gamma-cyclodextrins (CD) were prepared by the solvent injection technique. A new synthesis of lipophilic derivatives of gamma- CD was developed in this work. Curcumin (CU), a natural polyphenol with antitumor, antioxidant and anti-inflammatory properties, was used as model drug. SLNs mean sizes were in the 250– 800 nm range and afforded CU entrapment efficiency in the 12–85% range. The presence of CD derivatives with almost the same chain length of TG induced an improvement of nanoparticle characteristics decreasing mean size values and increasing CU entrapment efficiency. A significant reduction in CU photodegradation was noted only when the drug was vehicled in tristearin-SLN, which became less pronounced in the presence of CD-derivatives, determining a loss in photoprotection. The hydrolytic stability of curcumin was highly improved by drug loading in tristearin-SLN, and only slightly by loading it in tricaprin- SLN, and this seemed not to be influenced by the presence of CD derivatives. Skin uptake studies revealed an increase in CU skin accumulation when CU was loaded in SLN obtained with all CD derivatives, particularly with most lipophilic one.
| Titolo: | Influence of alpha- and gamma- cyclodextrin lipophilic derivativeson curcumin-loaded SLN | |
| Autori Riconosciuti: | ||
| Autori: | Chirio D.; Gallarate M.; Trotta M.; Carlotti M.E.; Calcio Gaudino E.; Cravotto G. | |
| Data di pubblicazione: | 2009 | |
| Abstract: | Solid lipid nanoparticles (SLN) made of different triglycerides (TG) in the presence and in the absence of various modified alpha- and gamma-cyclodextrins (CD) were prepared by the solvent injection technique. A new synthesis of lipophilic derivatives of gamma- CD was developed in this work. Curcumin (CU), a natural polyphenol with antitumor, antioxidant and anti-inflammatory properties, was used as model drug. SLNs mean sizes were in the 250– 800 nm range and afforded CU entrapment efficiency in the 12–85% range. The presence of CD derivatives with almost the same chain length of TG induced an improvement of nanoparticle characteristics decreasing mean size values and increasing CU entrapment efficiency. A significant reduction in CU photodegradation was noted only when the drug was vehicled in tristearin-SLN, which became less pronounced in the presence of CD-derivatives, determining a loss in photoprotection. The hydrolytic stability of curcumin was highly improved by drug loading in tristearin-SLN, and only slightly by loading it in tricaprin- SLN, and this seemed not to be influenced by the presence of CD derivatives. Skin uptake studies revealed an increase in CU skin accumulation when CU was loaded in SLN obtained with all CD derivatives, particularly with most lipophilic one. | |
| Volume: | 65 | |
| Pagina iniziale: | 391 | |
| Pagina finale: | 402 | |
| Digital Object Identifier (DOI): | 10.1007/s10847-009-9597-7 | |
| Parole Chiave: | Alkylated cyclodextrins; Solid lipid nanoparticles; Curcumin; Synthesis | |
| Rivista: | JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| SLN curcumina J MIcroenc 2011.pdf | PDF EDITORIALE | Accesso riservato | Utenti riconosciuti Richiedi una copia | |
| Curcumin CD-SLN open access.pdf | PREPRINT (PRIMA BOZZA) | Accesso aperto | Open Access Visualizza/Apri |
http://hdl.handle.net/2318/62900
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