An isolated polypeptide comprising any amino acid fragment of unacylated ghrelin or any analog thereof, wherein the polypeptide has an activity selected from the group consisting of a) decreasing blood glucose levels; b) increasing insulin secretion an/or sensitivity; c) binding to insulin-secreting cells; and d) promoting survival of insulin-secreting cells. As well as the use of the polypeptide in the treatment of a disorder associated with impaired glucose metabolism.

Unacylated ghrelin as therapeutic agent in the treatment of metabolic disorders

GHIGO, Ezio;GRANATA, Riccarda
2008-01-01

Abstract

An isolated polypeptide comprising any amino acid fragment of unacylated ghrelin or any analog thereof, wherein the polypeptide has an activity selected from the group consisting of a) decreasing blood glucose levels; b) increasing insulin secretion an/or sensitivity; c) binding to insulin-secreting cells; and d) promoting survival of insulin-secreting cells. As well as the use of the polypeptide in the treatment of a disorder associated with impaired glucose metabolism.
2008
IPC8 Class: AA61K3802FI USPC Class: 514 2
Alizé Pharma SAS
http://www.faqs.org/patents/app/20080312133
Ezio Ghigo; Aart Jan Van Der Lely; Riccarda Granata
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/68703
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