Quantal release of catecholamines is commonly detected from single chromaffin cells as amperomet-ric currents by means of carbon-fiber microelectrodes, with a ms temporal resolution and high sensitivity, but with low spatial resolution (~30 µm2). To overcome these limitations, we designed a new planar device of boron-doped (B-doped) nanocrystalline diamond (NCD) with four separate re-cording areas in a circular region of 25 µm diameter. Early results are presented.
NCD microelectrodes for detecting quantal release of catecholamines from chromaffin cells
MARCANTONI, Andrea;CARABELLI, Valentina;CARBONE, Emilio
2008-01-01
Abstract
Quantal release of catecholamines is commonly detected from single chromaffin cells as amperomet-ric currents by means of carbon-fiber microelectrodes, with a ms temporal resolution and high sensitivity, but with low spatial resolution (~30 µm2). To overcome these limitations, we designed a new planar device of boron-doped (B-doped) nanocrystalline diamond (NCD) with four separate re-cording areas in a circular region of 25 µm diameter. Early results are presented.
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