Quantal release of catecholamines is commonly detected from single chromaffin cells as amperomet-ric currents by means of carbon-fiber microelectrodes, with a ms temporal resolution and high sensitivity, but with low spatial resolution (~30 µm2). To overcome these limitations, we designed a new planar device of boron-doped (B-doped) nanocrystalline diamond (NCD) with four separate re-cording areas in a circular region of 25 µm diameter. Early results are presented.

NCD microelectrodes for detecting quantal release of catecholamines from chromaffin cells

MARCANTONI, Andrea;CARABELLI, Valentina;CARBONE, Emilio
2008

Abstract

Quantal release of catecholamines is commonly detected from single chromaffin cells as amperomet-ric currents by means of carbon-fiber microelectrodes, with a ms temporal resolution and high sensitivity, but with low spatial resolution (~30 µm2). To overcome these limitations, we designed a new planar device of boron-doped (B-doped) nanocrystalline diamond (NCD) with four separate re-cording areas in a circular region of 25 µm diameter. Early results are presented.
6th Int. Meeting on Substrate-Integrated Microelectrodes
Reutlingen
8-11 Luglio 2008
Proceeding MEA Meeting 2008
BIOPRO Edition
5
333
334
3938345055
Biosensori elettrochimici; catecolamine; secrezione vescicolare; cellule cromaffini
Pasquarelli A; Dipalo M; Kohn E; Marcantoni A; Carabelli V; Carbone E
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/68916
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