SKIN AS A BIDIRECTIONAL BARRIER FOR THE ABSORPTION AND EXCRETION OF XENOBIOTICS. PRELIMINARY IN VITRO DATA. The evaluation of toxic substances in the sweat or in the stratum corneum could have interesting future implications for biological monitoring in exposed workers. The authors demonstrated in vitro skin secrection of cobalt using reversed Franz cells. The application of a Co solution to the dermal site of the skin caused a flux of Co toward the external site of the skin of 0,0166 ± 0,02 μg/cm2/hour. The in-vitro model proved that in vivo the skin can have a role both in the absorption and in the secrection of toxicants.
Skin as a bidirectional barrier for the absorption and excretion of xenobiotics. preliminary in vitro data
MAINA, Giovanni
2004-01-01
Abstract
SKIN AS A BIDIRECTIONAL BARRIER FOR THE ABSORPTION AND EXCRETION OF XENOBIOTICS. PRELIMINARY IN VITRO DATA. The evaluation of toxic substances in the sweat or in the stratum corneum could have interesting future implications for biological monitoring in exposed workers. The authors demonstrated in vitro skin secrection of cobalt using reversed Franz cells. The application of a Co solution to the dermal site of the skin caused a flux of Co toward the external site of the skin of 0,0166 ± 0,02 μg/cm2/hour. The in-vitro model proved that in vivo the skin can have a role both in the absorption and in the secrection of toxicants.
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