Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.

Forensic mitochondrial DNA analysis in HIV-infected patients treated with nucleoside reverse transcriptase inhibitors

ROBINO, Carlo;BIGLINO, Alberto;GINO, Sarah;TORRE, Carlo
2009

Abstract

Hypervariable regions HV1 and HV2 of the mitochondrial DNA control region were sequenced in pre-therapy (serum) and post-therapy (saliva, hair) biological samples collected from HIV-infected patients (n = 13) treated with nucleoside reverse transcriptase inhibitors (NRTIs). Occurrence of length/point heteroplasmic mutations as a consequence of treatment with NRTIs was evaluated. The observed rate of length heteroplasmy in the analyzed samples was consistent with values previously reported in untreated subjects, whereas no evidence of point heteroplasmy in post-treatment tissue samples was seen.
23rd International ISFG Congress
Buenos Aires
15.9.2009-18.9.2009
2(1)
501
502
FORENSIC SCIENCE INTERNATIONAL: GENETICS SUPPLEMENT SERIES
Mitochondrial DNA; Control region; Reverse transcriptase inhibitors; HIV; Hair
ROBINO C.; COLLA C.; BIGLINO A.; DEGIOANNI M.; GINO S.; TORRE C.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/72313
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