The invention relates to human liver pluripotent progenitor cell lines which express hepatic cell markers such as albumin and alpha-fetoprotein and do not express some of the markers which are typical of oval stem cells. Also disclosed is a method of isolating the cell lines of the invention, methods for differentiating said cells into a plurality of different cell lineages, methods for conditional immortalization and metabolic selection of said cells, as well as the use of the cell lines of the invention for preparing a medicament with osteogenic differentiation activity or liver injury regeneration activity.

Liver progenitor cells

BUSSOLATI, Benedetta;BUTTIGLIERI, Stefano;CAMUSSI, Giovanni
2005

Abstract

The invention relates to human liver pluripotent progenitor cell lines which express hepatic cell markers such as albumin and alpha-fetoprotein and do not express some of the markers which are typical of oval stem cells. Also disclosed is a method of isolating the cell lines of the invention, methods for differentiating said cells into a plurality of different cell lineages, methods for conditional immortalization and metabolic selection of said cells, as well as the use of the cell lines of the invention for preparing a medicament with osteogenic differentiation activity or liver injury regeneration activity.
WO2009/150199 A1
FRESENIUS MEDICAL CARE DE GMBH [DE]
http://ep.espacenet.com/
Human liver stem cells
MARIA BEATRIZ HERRERA SANCHEZ; BENEDETTA BUSSOLATI; STEFANO BUTTIGLIERI; GIOVANNI CAMUSSI
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/72843
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