Importance of the field: Cachexia is a syndrome characterized by body weight loss and metabolic abnormalities. It is a frequent feature of patients affected by chronic pathologies, including cancer. Neoplastic patients with cachexia show increased morbidity and mortality rates, benefit less from antineoplastic therapies, and have a poorer quality of life. Among the general mechanisms proposed to account for cachexia, anorexia and altered homeostasis of hormones and cytokines appear to play a major role. Areas covered in this review: The present review will focus on antiinflammatory drugs useful for the treatment of cancer-related anorexia and cachexia. What the reader will gain: Molecules able to block cytokine production or biological activity are currently under evaluation. At present, none of them has been authorized for the clinical treatment of cancer-related anorexia and cachexia, since the few published clinical trials lead to contrasting results, and others are still pending. Take home message: Considering the multifactorial pathogenesis of cancerrelated anorexia and cachexia, combination protocols are probably the better choice. In this regard, anti-cytokine strategies should be pursued and included in the treatment of neoplastic patients, although cytokines modulate a number of processes.

Anticytokine strategies for the treatment of cancer-related anorexia and cachexia

PENNA, FABIO;MINERO, Valerio Giacomo;COSTAMAGNA, DOMIZIANA;BONELLI, Gabriella;BACCINO, Francesco Maria;COSTELLI, Paola
2010

Abstract

Importance of the field: Cachexia is a syndrome characterized by body weight loss and metabolic abnormalities. It is a frequent feature of patients affected by chronic pathologies, including cancer. Neoplastic patients with cachexia show increased morbidity and mortality rates, benefit less from antineoplastic therapies, and have a poorer quality of life. Among the general mechanisms proposed to account for cachexia, anorexia and altered homeostasis of hormones and cytokines appear to play a major role. Areas covered in this review: The present review will focus on antiinflammatory drugs useful for the treatment of cancer-related anorexia and cachexia. What the reader will gain: Molecules able to block cytokine production or biological activity are currently under evaluation. At present, none of them has been authorized for the clinical treatment of cancer-related anorexia and cachexia, since the few published clinical trials lead to contrasting results, and others are still pending. Take home message: Considering the multifactorial pathogenesis of cancerrelated anorexia and cachexia, combination protocols are probably the better choice. In this regard, anti-cytokine strategies should be pursued and included in the treatment of neoplastic patients, although cytokines modulate a number of processes.
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F. Penna; V.G. Minero; D. Costamagna; G. Bonelli; F.M. Baccino; P. Costelli
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/76556
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