JAK2 V617F mutation was identified in 36 (56.3%) of 64 patients with essential trombocythemia. Patients with JAK2 V617F mutation have a PV-like phenotype (high haemoglobin level and hypercellular marrow). Furthermore, JAK2 V617 mutational status is strongly associated with morphological changes in the megakaryocyte lineage, such as hyperplasia, dysplasia, size, nuclear morphology and clustering, as detected by the BM biopsy. Therefore, JAK2 V617 mutation identifies a distinct morphologic subtype of ET.

JAK2V617F MUTATIONAL STATUS IS ASSOCIATED WITH DIFFERENT PHENOTYPES IN ESSENTIAL TROMBOCYTHEMIA

PICH, Achille;RIERA, Ludovica;SISMONDI, Francesca;
2010

Abstract

JAK2 V617F mutation was identified in 36 (56.3%) of 64 patients with essential trombocythemia. Patients with JAK2 V617F mutation have a PV-like phenotype (high haemoglobin level and hypercellular marrow). Furthermore, JAK2 V617 mutational status is strongly associated with morphological changes in the megakaryocyte lineage, such as hyperplasia, dysplasia, size, nuclear morphology and clustering, as detected by the BM biopsy. Therefore, JAK2 V617 mutation identifies a distinct morphologic subtype of ET.
XVth Meeting of the European Association for Haematopathology
Uppsala, Sweden
September 25-30, 2010
Abstract and Workshop Book
European Association for Haematopathology
1
13
14
Essential Trombocythemia; JAK2V617F mutation; phenotype
Pich A; Riera L; Godio L; Sismondi F; Francia di Celle P
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/80560
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact