Nowadays compounds that exhibit antimicrobial effect, are under scrutiny. It is known that when a new anti-infective agent appears, the strains of bacteria which are resistant to these drugs appear also. In this regard, there is a need of new compounds with new mechanisms of exposure to pathogenic microorganisms. Porphyrins are widely used in medicine as an individual reagents and as components of drugs, mainly due to their selective light and dark cytotoxicity. Meso-substituted porphyrins are well-known photosensitizers for photodynamic therapy. They are able to penetrate into the cells across the plasma membrane by diffusion or endotsitolize, depending on their size, chemical properties and charge. The ability to easily "tuning" properties of porphyrins makes these compounds particularly attractive in the fight against resistant bacteria.

Water-soluble meso-substituted porphyrins as effective antimicrobial agents against Gram-positive and gram-negative bacteria

BALANTSEVA, ELENA;
2009

Abstract

Nowadays compounds that exhibit antimicrobial effect, are under scrutiny. It is known that when a new anti-infective agent appears, the strains of bacteria which are resistant to these drugs appear also. In this regard, there is a need of new compounds with new mechanisms of exposure to pathogenic microorganisms. Porphyrins are widely used in medicine as an individual reagents and as components of drugs, mainly due to their selective light and dark cytotoxicity. Meso-substituted porphyrins are well-known photosensitizers for photodynamic therapy. They are able to penetrate into the cells across the plasma membrane by diffusion or endotsitolize, depending on their size, chemical properties and charge. The ability to easily "tuning" properties of porphyrins makes these compounds particularly attractive in the fight against resistant bacteria.
10th International conference on physical and coordination chemistry of porphyrins and their analogues
Ivanovo
1-4 Juny, 2009
10th International conference on physical and coordination chemistry of porphyrins and their analogues
Berezin D.B.
111
112
http://www.isuct.ru/ICPC10
porphyrins; antimicrobial agent; bacteria
Ekimova M.S.; Balantseva E.V.; Kuznetsov O.Yu.; Antina E.V.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/81214
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact