Resveratrol in solid lipid nanoparticles

This report investigates the possibility of producing solid lipid nanoparticles as protective vehicle of resveratrol, an antioxidant characterised by a fast trans-cis isomerisation. SLN aqueous dispersions were produced by hot melt homogenisation technique and characterised. It was found that the presence of tetradecyl-γ-cyclodextrin in SLN formulation induced an improvement of nanoparticle characteristics. Moreover a significant reduction in resveratrol photodegradation was noted when the molecule was entrapped in SLN which became more pronounced in the presence of tetradecyl-γ-cyclodextrin. A notable in vitro porcine skin accumulation and an increased antioxidative efficacy were observed by entrapping resveratrol in nanoparticles.