AN ISOLATED MONOPHOSPHORYLATED PEPTIDE DERIVED FROM HUMAN ALPHA-ENOLASE USEFUL FOR DIAGNOSIS AND TREATMENT OF PANCREATIC ADENOCARCINOMA, ANTIBODIES DIRECTED AGAINST THE SAID MONOPHOSPHORYLATED PEPTIDE, AND USES THEREOF

The invention relates to an isolated peptide of 12-20 amino acids in length comprising the amino acid sequence SEQ ID NO: 1, said peptide being characterised in that it contains a single phosphorylation on the serine residue at position 8 of SEQ ID NO:1. The invention further relates to a human monophosphorylated alpha-enolase isoform containing a single phosphorylation on the serine residue at position 419 of the human alpha-enolase amino acid sequence (SEQ ID NO:2) and optionally other post-translational modifications, as well as antibodies capable of specifically binding the peptide and/or the isoform of the invention. The peptide, the isoform and the antibodies of the invention are useful in the diagnosis and/or treatment of pancreatic adenocarcinoma.