Purpose: It has been supposed that prostaglandin analogues (PGA) could reduce the central corneal thickness (CCT), while topical carbonic anydrasis inhibitors (TCAI) could increase CCT. The aim of the study was to evaluate whether patients treated with PGA or TCAI could change CCT. Methods: This is a cross-sectional study. From 16 different glaucoma centers, at least 50 glaucomatous patients were saved on the Italian Glaucoma Register (IGR). 816 glaucomatous patients were included in the IGR. The diagnosis of glaucoma was based on visual field examination, optic nerve head analysis, intraocular pressure (IOP) measurements and gonioscopy. For the purpose of this projects only patients treated with PGA and TCAI were considered and two age-matched subgroups were created: one treated with PGA and the other with TCAI. For the PGA subgroup 175 patients were included, while for the TCAI subgroup 168 patients. CCT, ophthalmoscopic cup/disc ratio (C/D), mean deviation (MD), pattern standard deviation (PSD) and Intraocular pressure (IOP) were considered for each patient. Student's T-test was used to compare the two subgroups. Results: The mean age of the PGA group was 66.35 ± 12.17 years, while it was 65.17 ± 12.52 years for the TCAI group. No significant difference was found for CCT (543.75 ± 35 and 544 ± 35, respectively), C/D (0.55 ± 0.2 and 0.53 ± 0.2, respectively), MD (-4.5 ± 4.9 and -5.4 ± 6.4, respectively), PSD (4.6 ± 3.4 and 4.6 ± 4.9, respectively) and IOP (15.9 ± 3.3 and 15.7 ± 2.9, respectively) between the two groups. Conclusion: No significant difference in CCT was found between patients treated with PGA and TCAI, suggesting that These topical medication did not change the CCT. Supported by Italian Glaucoma Register Association and Associazione Italiana Studio Glaucoma (AISG).

Do the prostaglandin analogues reduce central cornea thickness?

ROLLE, Teresa;
2010-01-01

Abstract

Purpose: It has been supposed that prostaglandin analogues (PGA) could reduce the central corneal thickness (CCT), while topical carbonic anydrasis inhibitors (TCAI) could increase CCT. The aim of the study was to evaluate whether patients treated with PGA or TCAI could change CCT. Methods: This is a cross-sectional study. From 16 different glaucoma centers, at least 50 glaucomatous patients were saved on the Italian Glaucoma Register (IGR). 816 glaucomatous patients were included in the IGR. The diagnosis of glaucoma was based on visual field examination, optic nerve head analysis, intraocular pressure (IOP) measurements and gonioscopy. For the purpose of this projects only patients treated with PGA and TCAI were considered and two age-matched subgroups were created: one treated with PGA and the other with TCAI. For the PGA subgroup 175 patients were included, while for the TCAI subgroup 168 patients. CCT, ophthalmoscopic cup/disc ratio (C/D), mean deviation (MD), pattern standard deviation (PSD) and Intraocular pressure (IOP) were considered for each patient. Student's T-test was used to compare the two subgroups. Results: The mean age of the PGA group was 66.35 ± 12.17 years, while it was 65.17 ± 12.52 years for the TCAI group. No significant difference was found for CCT (543.75 ± 35 and 544 ± 35, respectively), C/D (0.55 ± 0.2 and 0.53 ± 0.2, respectively), MD (-4.5 ± 4.9 and -5.4 ± 6.4, respectively), PSD (4.6 ± 3.4 and 4.6 ± 4.9, respectively) and IOP (15.9 ± 3.3 and 15.7 ± 2.9, respectively) between the two groups. Conclusion: No significant difference in CCT was found between patients treated with PGA and TCAI, suggesting that These topical medication did not change the CCT. Supported by Italian Glaucoma Register Association and Associazione Italiana Studio Glaucoma (AISG).
2010
EGS 2010
MADRID
12-17 settembre
EGS Final Program
EGS
2.99
2.99
M. Iester; P. Brusini; P. Frezzotti; G. Manni; D. Paoli; M. Rolando; T. Rolle; M. Uva;R. Altafini; E. Martini; G. Milano; A. Perdicchi; G. Rossi; F. Scrimieri; M. Vetrugno; L. Rossetti; A. Rossi; S. Telani 1
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/85101
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