Vaccines against oncoantigens halt early neoplastic lesions in several cancer-prone, genetically engineered mouse models, whereas their ability to prevent chemical carcinogenesis has not been explored. This is a significant issue since exposure to chemical mutagens is responsible for a substantial percentage of cancers worldwide. Here we show that the archetypal oncoantigen ERBB2 is transiently overexpressed in Syrian hamsters during the early stages of 7,12-dimethylbenz[α]anthracene (DMBA)-induced oral carcinogenesis. Repeated DNA vaccinations against ERBB2 significantly reduce the number, size and severity of oral lesions in a manner directly proportional to the anti-ERBB2 antibody response. These results support the prospects of vaccines as a fresh strategy in the management of individuals at risk for exposure to defined carcinogenic agents.

A DNA vaccine against ERBB2 impairs chemical carcinogenesis in random-bred hamsters

BERTA, Giovanni Nicolao;SPRIO, ANDREA ELIO;SPADARO, Michela;SALAMONE, PAOLINA;DI SCIPIO, FEDERICA;MOGNETTI, Barbara;PAPOTTI, Mauro Giulio;FORNI, Guido;CAVALLO, Federica
2011

Abstract

Vaccines against oncoantigens halt early neoplastic lesions in several cancer-prone, genetically engineered mouse models, whereas their ability to prevent chemical carcinogenesis has not been explored. This is a significant issue since exposure to chemical mutagens is responsible for a substantial percentage of cancers worldwide. Here we show that the archetypal oncoantigen ERBB2 is transiently overexpressed in Syrian hamsters during the early stages of 7,12-dimethylbenz[α]anthracene (DMBA)-induced oral carcinogenesis. Repeated DNA vaccinations against ERBB2 significantly reduce the number, size and severity of oral lesions in a manner directly proportional to the anti-ERBB2 antibody response. These results support the prospects of vaccines as a fresh strategy in the management of individuals at risk for exposure to defined carcinogenic agents.
4
7
994
1001
ERBB2; Squamous cells carcinoma; Oral cancer
G N Berta; A E Sprio; M Iezzi; M Spadaro; S Cappia; P Salamone; F Di Scipio; B Mognetti; M Papotti; P Musiani; G Forni; F Cavallo
File in questo prodotto:
File Dimensione Formato  
Cancer prevention research.pdf

Accesso riservato

Descrizione: Articolo principale
Tipo di file: PDF EDITORIALE
Dimensione 784.89 kB
Formato Adobe PDF
784.89 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/86631
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 6
social impact