8-methoxsalen was vehicled in nanoemulsion and in solid lipid nanoparticles (SLN) prepared by hot homogenisation technique, in order to be used in the topical psoralen UVA (PUVA) therapy. Drug entrapment efficiency in nanoparticles was improved by choosing the appropriate lipid matrix. The use of α-tocopherol in the lipid phase reduces 8-methoxsalen induced photo-oxidation of porcine skin, which was evaluated in vitro by MDA (malondialdehyde) test: this result is promising to reduce in vivo human skin irritation after PUVA therapy, which can be attributed to skin photo-oxidation.
Lipid Nanosystems in Topical PUVA Therapy
BATTAGLIA, Luigi Sebastiano;PEIRA, Elena;SAPINO, Simona;GALLARATE, Marina
2012-01-01
Abstract
8-methoxsalen was vehicled in nanoemulsion and in solid lipid nanoparticles (SLN) prepared by hot homogenisation technique, in order to be used in the topical psoralen UVA (PUVA) therapy. Drug entrapment efficiency in nanoparticles was improved by choosing the appropriate lipid matrix. The use of α-tocopherol in the lipid phase reduces 8-methoxsalen induced photo-oxidation of porcine skin, which was evaluated in vitro by MDA (malondialdehyde) test: this result is promising to reduce in vivo human skin irritation after PUVA therapy, which can be attributed to skin photo-oxidation.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
articolo psoralene.pdf
Accesso riservato
Tipo di file:
PDF EDITORIALE
Dimensione
389.64 kB
Formato
Adobe PDF
|
389.64 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
|
psoralene.pdf
Open Access dal 12/08/2013
Tipo di file:
POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione
378.75 kB
Formato
Adobe PDF
|
378.75 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
