Sfoglia per Autore
Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors
2021-01-01 Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
In the search for new NLRP3 inhibitors: chemical modulation of the 1-(piperidin-4-yl)-1,3-dihydro-2 Hbenzo[d]imidazole-2-one scaffold
2021-01-01 Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A. MacDonald, Massimo Bertinaria
Improvement of metabolic weakness of new human Dihydroorotate Dehydrogenase inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold
2021-01-01 Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Agnese Chiara Pippione, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Targeting myeloid leukemias using human Dihydroorotate Dehydrogenase inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold: overcoming of metabolic issues
2021-01-01 Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Agnese Chiara Pippione, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli.
A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli.
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli
Design of new human Dihydroorotate Dehydrogenase inhibitors: amide bioisosterism in MEDS433 optimization
2021-01-01 Martino Elena, Villella Noemi, Vigato Chiara, Cerrina Matteo, Bersani Matteo, Giorgis Marta, Sainas Stefano, Boschi Donatella, Lolli Marco Lucio
Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication
2021-01-01 Luganini, Anna; Sibille, Giulia; Mognetti, Barbara; Sainas, Stefano; Pippione, Agnese Chiara; Giorgis, Marta; Boschi, Donatella; Lolli, Marco L.; Gribaudo, Giorgio
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety
2021-01-01 Sainas S.; Giorgis M.; Circosta P.; Gaidano V.; Bonanni D.; Pippione A.C.; Bagnati R.; Passoni A.; Qiu Y.; Cojocaru C.F.; Canepa B.; Bona A.; Rolando B.; Mishina M.; Ramondetti C.; Buccinna B.; Piccinini M.; Houshmand M.; Cignetti A.; Giraudo E.; Al-Karadaghi S.; Boschi D.; Saglio G.; Lolli M.L.
The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia
2021-01-01 Gaidano V.; Houshmand M.; Vitale N.; Carra G.; Morotti A.; Tenace V.; Rapelli S.; Sainas S.; Pippione A.C.; Giorgis M.; Boschi D.; Lolli M.L.; Cilloni D.; Cignetti A.; Saglio G.; Circosta P.
Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor
2021-01-01 Gastaldi S.; Boscaro V.; Gianquinto E.; Sandall C.F.; Giorgis M.; Marini E.; Blua F.; Gallicchio M.; Spyrakis F.; Macdonald J.A.; Bertinaria M.
Inibitori della diidroorotato deidrogenasi umana (hDHODH) per l'uso come antivirali
2020-01-01 Boschi Donatella, Giorgis Marta, Lolli Marco Lucio, Saglio Giuseppe, Martinelli Giovanni
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors.
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML)
2019-01-01 Giulia De Simone, Stefano Sainas, Marilena Marraudino, Agnese Chiara Pippione, Brigitta Bonaldo, Alice Passoni, Marta Giorgis, Barbara Rolando, Donatella Boschi, Marco Lucio Lolli
Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor.
2019-01-01 Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Methotrexate-Loaded Solid Lipid Nanoparticles: Protein Functionalization to Improve Brain Biodistribution
2019-01-01 Muntoni, Elisabetta; Martina, Katia; Marini, Elisabetta; Giorgis, Marta; Lazzarato, Loretta; Salaroglio, Iris Chiara; Riganti, Chiara; Lanotte, Michele; Battaglia, Luigi
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies
2019-01-01 Pippione, Agnese C; Sainas, Stefano; Goyal, Parveen; Fritzson, Ingela; Cassiano, Gustavo C; Giraudo, Alessandro; Giorgis, Marta; Tavella, Tatyana A; Bagnati, Renzo; Rolando, Barbara; Caing-Carlsson, Rhawnie; Costa, Fabio T M; Andrade, Carolina Horta; Al-Karadaghi, Salam; Boschi, Donatella; Friemann, Rosmarie; Lolli, Marco L
Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML)
2019-01-01 Giulia De Simone, Stefano Sainas, Marilena Marraudino, Agnese Chiara Pippione, Brigitta Bonaldo, Alice Passoni, Marta Giorgis, Barbara Rolando, Donatella Boschi, Marco Lucio Lolli
Targeting NLRP3 inflammasome: development of new covalent and non-covalent inhibitors of ATPase activity
2019-01-01 Elisabetta Marini, Simone Gastaldi, Marta Giorgis, Marco Marino, Valentina Boscaro, Margherita Gallicchio, Massimo Bertinaria
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors | 2021 | Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| In the search for new NLRP3 inhibitors: chemical modulation of the 1-(piperidin-4-yl)-1,3-dihydro-2 Hbenzo[d]imidazole-2-one scaffold | 2021 | Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A. MacDonald, Massimo Bertinaria | |
| Improvement of metabolic weakness of new human Dihydroorotate Dehydrogenase inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold | 2021 | Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Agnese Chiara Pippione, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| Targeting myeloid leukemias using human Dihydroorotate Dehydrogenase inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold: overcoming of metabolic issues | 2021 | Chiara Vigato, Stefano Sainas, Marta Giorgis, Paola Circosta, Alice Passoni, Agnese Chiara Pippione, Renzo Bagnati, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli. | |
| A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli. | |
| Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor | 2021 | Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli | |
| Design of new human Dihydroorotate Dehydrogenase inhibitors: amide bioisosterism in MEDS433 optimization | 2021 | Martino Elena, Villella Noemi, Vigato Chiara, Cerrina Matteo, Bersani Matteo, Giorgis Marta, Sainas Stefano, Boschi Donatella, Lolli Marco Lucio | |
| Effective deploying of a novel DHODH inhibitor against herpes simplex type 1 and type 2 replication | 2021 | Luganini, Anna; Sibille, Giulia; Mognetti, Barbara; Sainas, Stefano; Pippione, Agnese Chiara; Giorgis, Marta; Boschi, Donatella; Lolli, Marco L.; Gribaudo, Giorgio | |
| Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety | 2021 | Sainas S.; Giorgis M.; Circosta P.; Gaidano V.; Bonanni D.; Pippione A.C.; Bagnati R.; Passoni A.; Qiu Y.; Cojocaru C.F.; Canepa B.; Bona A.; Rolando B.; Mishina M.; Ramondetti C.; Buccinna B.; Piccinini M.; Houshmand M.; Cignetti A.; Giraudo E.; Al-Karadaghi S.; Boschi D.; Saglio G.; Lolli M.L. | |
| The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia | 2021 | Gaidano V.; Houshmand M.; Vitale N.; Carra G.; Morotti A.; Tenace V.; Rapelli S.; Sainas S.; Pippione A.C.; Giorgis M.; Boschi D.; Lolli M.L.; Cilloni D.; Cignetti A.; Saglio G.; Circosta P. | |
| Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor | 2021 | Gastaldi S.; Boscaro V.; Gianquinto E.; Sandall C.F.; Giorgis M.; Marini E.; Blua F.; Gallicchio M.; Spyrakis F.; Macdonald J.A.; Bertinaria M. | |
| Inibitori della diidroorotato deidrogenasi umana (hDHODH) per l'uso come antivirali | 2020 | Boschi Donatella, Giorgis Marta, Lolli Marco Lucio, Saglio Giuseppe, Martinelli Giovanni | |
| A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors. | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML) | 2019 | Giulia De Simone, Stefano Sainas, Marilena Marraudino, Agnese Chiara Pippione, Brigitta Bonaldo, Alice Passoni, Marta Giorgis, Barbara Rolando, Donatella Boschi, Marco Lucio Lolli | |
| Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor. | 2019 | Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| Methotrexate-Loaded Solid Lipid Nanoparticles: Protein Functionalization to Improve Brain Biodistribution | 2019 | Muntoni, Elisabetta; Martina, Katia; Marini, Elisabetta; Giorgis, Marta; Lazzarato, Loretta; Salaroglio, Iris Chiara; Riganti, Chiara; Lanotte, Michele; Battaglia, Luigi | |
| Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies | 2019 | Pippione, Agnese C; Sainas, Stefano; Goyal, Parveen; Fritzson, Ingela; Cassiano, Gustavo C; Giraudo, Alessandro; Giorgis, Marta; Tavella, Tatyana A; Bagnati, Renzo; Rolando, Barbara; Caing-Carlsson, Rhawnie; Costa, Fabio T M; Andrade, Carolina Horta; Al-Karadaghi, Salam; Boschi, Donatella; Friemann, Rosmarie; Lolli, Marco L | |
| Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML) | 2019 | Giulia De Simone, Stefano Sainas, Marilena Marraudino, Agnese Chiara Pippione, Brigitta Bonaldo, Alice Passoni, Marta Giorgis, Barbara Rolando, Donatella Boschi, Marco Lucio Lolli | |
| Targeting NLRP3 inflammasome: development of new covalent and non-covalent inhibitors of ATPase activity | 2019 | Elisabetta Marini, Simone Gastaldi, Marta Giorgis, Marco Marino, Valentina Boscaro, Margherita Gallicchio, Massimo Bertinaria |
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