The invention relates to hDHODH inhibitors for use as antiviral agents. The hDHODH inhibitors for use according to the invention are effective as inhibitors of the replication of a wide spectrum of both DNA and RNA viruses, including, i.a., Herpes simplex virus 1 (HSV- 1), Herpes simplex virus 2 (HSV-2), Influenza A virus, Influenza B virus, Respiratory syncytial virus (RSV), Severe acute respiratory syndrome coronavirus 1 (SARSCoV- 1), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome-related coronavirus (MERS-CoV).
Inibitori della diidroorotato deidrogenasi umana (hDHODH) per l'uso come antivirali
Boschi Donatella;Giorgis Marta;Lolli Marco Lucio;Saglio Giuseppe;
2020-01-01
Abstract
The invention relates to hDHODH inhibitors for use as antiviral agents. The hDHODH inhibitors for use according to the invention are effective as inhibitors of the replication of a wide spectrum of both DNA and RNA viruses, including, i.a., Herpes simplex virus 1 (HSV- 1), Herpes simplex virus 2 (HSV-2), Influenza A virus, Influenza B virus, Respiratory syncytial virus (RSV), Severe acute respiratory syndrome coronavirus 1 (SARSCoV- 1), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome-related coronavirus (MERS-CoV).
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