GAIDANO, Valentina
GAIDANO, Valentina
A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors.
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli.
Aberrant activation of ROS1 represents a new molecular defect in chronic myelomonocytic leukemia.
2013-01-01 Cilloni D; Carturan S; Bracco E; Campia V; Rosso V; Torti D; Calabrese C; Gaidano V; Niparuck P; Favole A; Signorino E; Iacobucci I; Morano A; De Luca L; Musto P; Frassoni F; Saglio G.
Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor
2021-01-01 Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli
Clinical significance of TFR2 and EPOR expression in bone marrow cells in myelodysplastic syndromes
2017-01-01 Di Savino, Augusta; Gaidano, Valentina; Palmieri, Antonietta; Crasto, Francesca; Volpengo, Alessandro; Lorenzatti, Roberta; Scaravaglio, Patrizia; Manello, Alessandro; Nicoli, Paolo; Gottardi, Enrico; Saglio, Giuseppe; Cilloni, Daniela; De Gobbi, Marco
Design and Application of a Novel PNA Probe for the Detection At Single Cell Level of JAK2(V617F) Mutation
2012-01-01 Cilloni D; Rosso V; Torti D; Carnuccio F; Serra A; Nicoli P; Gaidano V; Campia V; Signorino E; Calabrese C; Carturan S; Favole A; Saglio G; Frassoni F; Bracco E
Design and application of a novel PNA probe for the detection at single cell level of JAK2V617F mutation in Myeloproliferative Neoplasms
2013-01-01 Enrico Bracco;Valentina Rosso;Anna Serra;Francesca Carnuccio;Valentina Gaidano;Paolo Nicoli;Pellegrino Musto;Giuseppe Saglio;Francesco Frassoni;Daniela Cilloni
Detection of BCR-ABL T315I mutation by peptide nucleic acid directed PCR clamping and by peptide nucleic acid FISH
2015-01-01 Rosso, Valentina; Bracco, Enrico; Pedrola, Roberto; Carturan, Sonia; Signorino, Elisabetta; Petiti, Jessica; Calabrese, Chiara; Nicoli, Paolo; De Gobbi, Marco; Gaidano, Valentina; Gallo, Daniela; Ulisciani, Stefano; Fava, Carmen; Rege-Cambrin, Giovanna; Frassoni, Francesco; Saglio, Giuseppe; Cilloni, Daniela
Development of cellular and humoral response against WT1 protein vaccination in mice
2015-01-01 Nicoli, Paolo; Calabrese, Chiara; Pellegrino, Rosa Maria; Rosso, Valentina; Bracco, Enrico; Signorino, Elisabetta; Carturan, Sonia; Petiti, Jessica; Gallo, Daniela; Gaidano, Valentina; De Gobbi, Marco; Roetto, Antonella; Saglio, Giuseppe; Cilloni, Daniela
Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation
2018-01-01 Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli
DHODH inhibitors and leukemia: an emergent interest for new myeloid differentiation agents
2018-01-01 Sainas, S; Pippione, AC; Boschi, D; Gaidano, V; Circosta, P; Cignetti, A; Dosio, F; Lolli, ML
Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia
2022-01-01 Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors
2019-01-01 Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
ERYTHROFERRONE EXPRESSION LEVELS IN MYELODYSPLATIC SYNDROMES SHOW CLINICAL RELEVANCE
2017-01-01 Di Savino, Augusta; Savi, Arianna; Gallo, Daniela; Gaidano, Valentina; Scaravaglio, Patrizia; Mezzabotta, Mauro; Saglio, Giuseppe; Cilloni, Daniela; Marco, De Gobbi
Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine
2014-01-01 Valencia, A.; Masala, E.; Rossi, A.; Martino, A.; Sanna, A.; Buchi, F.; Canzian, F.; Cilloni, D.; Gaidano, V.; Voso, M.T.; Kosmider, O.; Fontenay, M.; Gozzini, A.; Bosi, A.; Santini, V
High frequency of endothelial colony forming cells marks a non-active myeloproliferative neoplasm with high risk of splanchnic vein thrombosis.
2010-01-01 Rosti V, Bonetti E, Bergamaschi G, Campanelli R, Guglielmelli P, Maestri M, Magrini U, Massa M, Tinelli C, Viarengo G, Villani L, Primignani M, Vannucchi AM, Frassoni F, Barosi G; AGIMM Investigators Collaborators (73) Vannucchi AM, Antonioli E, Bartalucci N, Biamonte F, Bogani C, Bosi A, Fjerza R, Guglielmelli P, Malevolti E, Pancrazzi A,Pieri L, Spolverini A, Susini MC, Tozzi L, Bortoluzzi S, Bisognin A, Coppe A, Marchioli R, Barosi G, Azzan C, Badalucco S,Balduini A, Bergamaschi G, Bonetti E, Campanelli R, Carolei A, Currao M, Isgrò MA, Lupo ML, Magrini U, Massa M, Magni V,Rosti V, Villani L, Cazzola M, Bernasconi P, Boggi S, Elena C, Gallì A, Malcovati L, Pascutto C, Passamonti F, Pietra D,Rumi E, Dejana E, Corada M, Giannotta M, Rambaldi A, Ferrari ML, Finazzi G, Finazzi MC, Magri M, Quaresmini G, Montalvo ML, Ricci C, Salmoiraghi S, Spinelli O, Amaru A, Golay J, Cilloni D, Arruga F, Bracco E, Carturan S, Gaidano V, Guerrasio A,Pradotto M, Manfredini R, Bianchi E, Montanari M, Salati S, Tagliafico E, Tenedini E, Zini R
Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors
2021-01-01 Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor.
2019-01-01 Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A differentiating and apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Stefano Sainas, Paola Circosta, Marta Giorgis, Agnese Chiara Pippione, Marilena Marraudino, Mohammad Houshmand, Brigitta Bonaldo, Valentina Gaidano, Alessandro Cignetti, Stefano Gotti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors. | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| A new pro-apoptotic therapy for Acute Myeloid Leukaemia using MEDS433, a potent human Dihydroorotate Dehydrogenase inhibitor | 2021 | Sainas Sainas, Paola Circosta, Noemi Villella, Elena Martino, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Caterina Peraldo Neia, Giovanna Chiorino, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco Lucio Lolli. | |
| Aberrant activation of ROS1 represents a new molecular defect in chronic myelomonocytic leukemia. | 2013 | Cilloni D; Carturan S; Bracco E; Campia V; Rosso V; Torti D; Calabrese C; Gaidano V; Niparuck P; Favole A; Signorino E; Iacobucci I; Morano A; De Luca L; Musto P; Frassoni F; Saglio G. | |
| Apoptotic and differentiating therapy for AML using potent human dihydroorotate dehydrogenase inhibitor | 2021 | Sainas Sainas, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lolli | |
| Clinical significance of TFR2 and EPOR expression in bone marrow cells in myelodysplastic syndromes | 2017 | Di Savino, Augusta; Gaidano, Valentina; Palmieri, Antonietta; Crasto, Francesca; Volpengo, Alessandro; Lorenzatti, Roberta; Scaravaglio, Patrizia; Manello, Alessandro; Nicoli, Paolo; Gottardi, Enrico; Saglio, Giuseppe; Cilloni, Daniela; De Gobbi, Marco | |
| Design and Application of a Novel PNA Probe for the Detection At Single Cell Level of JAK2(V617F) Mutation | 2012 | Cilloni D; Rosso V; Torti D; Carnuccio F; Serra A; Nicoli P; Gaidano V; Campia V; Signorino E; Calabrese C; Carturan S; Favole A; Saglio G; Frassoni F; Bracco E | |
| Design and application of a novel PNA probe for the detection at single cell level of JAK2V617F mutation in Myeloproliferative Neoplasms | 2013 | Enrico Bracco;Valentina Rosso;Anna Serra;Francesca Carnuccio;Valentina Gaidano;Paolo Nicoli;Pellegrino Musto;Giuseppe Saglio;Francesco Frassoni;Daniela Cilloni | |
| Detection of BCR-ABL T315I mutation by peptide nucleic acid directed PCR clamping and by peptide nucleic acid FISH | 2015 | Rosso, Valentina; Bracco, Enrico; Pedrola, Roberto; Carturan, Sonia; Signorino, Elisabetta; Petiti, Jessica; Calabrese, Chiara; Nicoli, Paolo; De Gobbi, Marco; Gaidano, Valentina; Gallo, Daniela; Ulisciani, Stefano; Fava, Carmen; Rege-Cambrin, Giovanna; Frassoni, Francesco; Saglio, Giuseppe; Cilloni, Daniela | |
| Development of cellular and humoral response against WT1 protein vaccination in mice | 2015 | Nicoli, Paolo; Calabrese, Chiara; Pellegrino, Rosa Maria; Rosso, Valentina; Bracco, Enrico; Signorino, Elisabetta; Carturan, Sonia; Petiti, Jessica; Gallo, Daniela; Gaidano, Valentina; De Gobbi, Marco; Roetto, Antonella; Saglio, Giuseppe; Cilloni, Daniela | |
| Development of Potent Human Dihydroorotate Dehydrogenase Inhibitors Able to Induces Myeloid Differentiation | 2018 | Stefano Sainas, Agnese C. Pippione, Davide Bonanni, Marta Giorgis, Elisa Lupino, Enrico Giraudo, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Marco Piccinini, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco L. Lolli | |
| DHODH inhibitors and leukemia: an emergent interest for new myeloid differentiation agents | 2018 | Sainas, S; Pippione, AC; Boschi, D; Gaidano, V; Circosta, P; Cignetti, A; Dosio, F; Lolli, ML | |
| Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia | 2022 | Houshmand, Mohammad; Vitale, Nicoletta; Orso, Francesca; Cignetti, Alessandro; Molineris, Ivan; Gaidano, Valentina; Sainas, Stefano; Giorgis, Marta; Boschi, Donatella; Fava, Carmen; Passoni, Alice; Gai, Marta; Geuna, Massimo; Sora, Federica; Iurlo, Alessandra; Abruzzese, Elisabetta; Breccia, Massimo; Mulas, Olga; Caocci, Giovanni; Castagnetti, Fausto; Taverna, Daniela; Oliviero, Salvatore; Pane, Fabrizio; Lolli, Marco Lucio; Circosta, Paola; Saglio, Giuseppe | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors | 2019 | Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| ERYTHROFERRONE EXPRESSION LEVELS IN MYELODYSPLATIC SYNDROMES SHOW CLINICAL RELEVANCE | 2017 | Di Savino, Augusta; Savi, Arianna; Gallo, Daniela; Gaidano, Valentina; Scaravaglio, Patrizia; Mezzabotta, Mauro; Saglio, Giuseppe; Cilloni, Daniela; Marco, De Gobbi | |
| Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine | 2014 | Valencia, A.; Masala, E.; Rossi, A.; Martino, A.; Sanna, A.; Buchi, F.; Canzian, F.; Cilloni, D.; Gaidano, V.; Voso, M.T.; Kosmider, O.; Fontenay, M.; Gozzini, A.; Bosi, A.; Santini, V | |
| High frequency of endothelial colony forming cells marks a non-active myeloproliferative neoplasm with high risk of splanchnic vein thrombosis. | 2010 | Rosti V, Bonetti E, Bergamaschi G, Campanelli R, Guglielmelli P, Maestri M, Magrini U, Massa M, Tinelli C, Viarengo G, Villani L, Primignani M, Vannucchi AM, Frassoni F, Barosi G; AGIMM Investigators Collaborators (73) Vannucchi AM, Antonioli E, Bartalucci N, Biamonte F, Bogani C, Bosi A, Fjerza R, Guglielmelli P, Malevolti E, Pancrazzi A,Pieri L, Spolverini A, Susini MC, Tozzi L, Bortoluzzi S, Bisognin A, Coppe A, Marchioli R, Barosi G, Azzan C, Badalucco S,Balduini A, Bergamaschi G, Bonetti E, Campanelli R, Carolei A, Currao M, Isgrò MA, Lupo ML, Magrini U, Massa M, Magni V,Rosti V, Villani L, Cazzola M, Bernasconi P, Boggi S, Elena C, Gallì A, Malcovati L, Pascutto C, Passamonti F, Pietra D,Rumi E, Dejana E, Corada M, Giannotta M, Rambaldi A, Ferrari ML, Finazzi G, Finazzi MC, Magri M, Quaresmini G, Montalvo ML, Ricci C, Salmoiraghi S, Spinelli O, Amaru A, Golay J, Cilloni D, Arruga F, Bracco E, Carturan S, Gaidano V, Guerrasio A,Pradotto M, Manfredini R, Bianchi E, Montanari M, Salati S, Tagliafico E, Tenedini E, Zini R | |
| Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors | 2021 | Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor. | 2019 | Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli |