GASTALDI, SIMONE
GASTALDI, SIMONE
SCIENZA E TECNOLOGIA DEL FARMACO
A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation
2018-01-01 Carolina Pellegrini, Matteo Fornai, Rocchina Colucci, Laura Benvenuti, Vanessa D’Antongiovanni, Gianfranco Natale, Federica Fulceri, Marta Giorgis, Elisabetta Marini, Simone Gastaldi, Massimo Bertinaria, Corrado Blandizzi, Luca Antonioli
Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor
2021-01-01 Gastaldi S.; Boscaro V.; Gianquinto E.; Sandall C.F.; Giorgis M.; Marini E.; Blua F.; Gallicchio M.; Spyrakis F.; Macdonald J.A.; Bertinaria M.
COMPOSTI INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO
2021-01-01 BLANDIZZI CORRADO, PELLEGRINI CAROLINA, FORNAI MATTEO, ANTONIOLI LUCA, COLUCCI ROCCHINA, BERTINARIA MASSIMO, MARINI ELISABETTA, BOSCARO VALENTINA, GASTALDI SIMONE, COCCO MATTIA
Covalent NLRP3 inhibitors: design strategies, synthesis and pharmacological characterization
2018-01-01 Gastaldi S., Introvigne M.L., Marino M., Marini E., Bertinaria M. Giorgis M.
Design and synthesis of encorafenib-based BRAF-V600E degraders
2022-01-01 Federica Blua, Marco Marino, Simone Gastaldi, Federica Maione, Eleonora Gianquinto, Federica Di Nicolantonio, Massimo Bertinaria
Design and synthesis of INF195, a new NLRP3 Inflammasome Inhibitor with ex vivo cardioprotective effect
2024-01-01 Francesca Boccato, Simone Gastaldi, Magalì Giordano, Elisabetta Marini, Francesca Spyrakis, Pasquale Pagliaro, Claudia Penna, Massimo Bertinaria
Development of covalent NLRP3 inflammasome inhibitors: chemistry and biological activity
2019-01-01 Bertinaria Massimo, Gastaldi Simone, Marini Elisabetta, Giorgis Marta
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation
2023-01-01 Gastaldi, Simone; Rocca, Carmine; Gianquinto, Eleonora; Granieri, Maria Concetta; Boscaro, Valentina; Blua, Federica; Rolando, Barbara; Marini, Elisabetta; Gallicchio, Margherita; De Bartolo, Anna; Romeo, Naomi; Mazza, Rosa; Fedele, Francesco; Pagliaro, Pasquale; Penna, Claudia; Spyrakis, Francesca; Bertinaria, Massimo; Angelone, Tommaso
Discovery of a septin-4 covalent binder with antimetastatic activity in a mouse model of melanoma
2024-01-01 Blua F.; Monge C.; Gastaldi S.; Clemente N.; Pizzimenti S.; Lazzarato L.; Senetta R.; Vittorio S.; Gigliotti C.L.; Boggio E.; Dianzani U.; Vistoli G.; Altomare A.A.; Aldini G.; Dianzani C.; Marini E.; Bertinaria M.
EVALUATION OF THE ANTIPYROPTOTIC ACTIVITY OF NEW INFLAMMASOME INHIBITORS
2021-01-01 Boscaro Valentina, Gastaldi Simone, Bertinaria Massimo, Gallicchio Margherita
In silico study of NLRP3: towards selective inhibition with small molecules
2019-01-01 Alejandro Gómez García, Simone Gastaldi, Giulia Fumero, Massimo Bertinaria, José Luis Medina Franco
In the search for new NLRP3 inhibitors: chemical modulation of the 1-(piperidin-4-yl)-1,3-dihydro-2 Hbenzo[d]imidazole-2-one scaffold
2021-01-01 Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A. MacDonald, Massimo Bertinaria
Inflammasome Biology Fundamentals, Role in Disease States, and Therapeutic Opportunities
2022-01-01 Massimo Bertinaria, Simone Gastaldi, Elisabetta Marini
Inhibition of NLRP3 ATPase activity: a new strategy to fight chronic inflammatory diseases
2019-01-01 Simone Gastaldi, Federica Blua, Marta Giorgis, Elisabetta Marini, Massimo Bertinaria
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein
2022-01-01 Marini, Elisabetta; Marino, Marco; Gionfriddo, Giulia; Maione, Federica; Pandini, Marta; Oddo, Daniele; Giorgis, Marta; Rolando, Barbara; Blua, Federica; Gastaldi, Simone; Marchiò, Serena; Kovachka, Sandra; Spyrakis, Francesca; Gianquinto, Eleonora; Di Nicolantonio, Federica; Bertinaria, Massimo
New anti-inflammatory agents for the treatment of chronic inflammatory diseases In the search of NLRP3 inflammasome inhibitors
2022-07-07
New inhibitors of NLRP3 inflammasome activation: pharmacological characterization in differentiated THP-1.
2022-01-01 Valentina Boscaro, Simone Gastaldi, Federica Blua, Massimo Bertinaria, Margherita Gallicchio
NEW NON-COVALENT INHIBITORS OF NLRP3 INFLAMMASOME ATPASE ACTIVITY
2019-01-01 Gastaldi, S; Marino, M.; Giorgis, M.; Marini, E.; Boscaro, V.; Gallicchio, M.; Bertinaria, M.
NLRP3 INFLAMMASOME-inhibiting compounds and the use thereof
2022-01-01 Blandizzi Corrado, Pellegrini Carolina, Fornai Matteo, Antonioli Luca, Colucci Rocchina, Bertinaria Massimo, Marini Elisabetta, Boscaro Valentina, Gastaldi Simone, Cocco Mattia
Pharmacological characterization of new NLRP3 inflammasome inhibitors.
2019-01-01 Valentina Boscaro, Simone Gastaldi, Marco Marino, Marta Giorgis, Elisabetta Marini, Massimo Bertinaria, Margherita Gallicchio
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation | 2018 | Carolina Pellegrini, Matteo Fornai, Rocchina Colucci, Laura Benvenuti, Vanessa D’Antongiovanni, Gianfranco Natale, Federica Fulceri, Marta Giorgis, Elisabetta Marini, Simone Gastaldi, Massimo Bertinaria, Corrado Blandizzi, Luca Antonioli | |
| Chemical modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazole-2-one scaffold as a novel NLRP3 inhibitor | 2021 | Gastaldi S.; Boscaro V.; Gianquinto E.; Sandall C.F.; Giorgis M.; Marini E.; Blua F.; Gallicchio M.; Spyrakis F.; Macdonald J.A.; Bertinaria M. | |
| COMPOSTI INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO | 2021 | BLANDIZZI CORRADO, PELLEGRINI CAROLINA, FORNAI MATTEO, ANTONIOLI LUCA, COLUCCI ROCCHINA, BERTINARIA MASSIMO, MARINI ELISABETTA, BOSCARO VALENTINA, GASTALDI SIMONE, COCCO MATTIA | |
| Covalent NLRP3 inhibitors: design strategies, synthesis and pharmacological characterization | 2018 | Gastaldi S., Introvigne M.L., Marino M., Marini E., Bertinaria M. Giorgis M. | |
| Design and synthesis of encorafenib-based BRAF-V600E degraders | 2022 | Federica Blua, Marco Marino, Simone Gastaldi, Federica Maione, Eleonora Gianquinto, Federica Di Nicolantonio, Massimo Bertinaria | |
| Design and synthesis of INF195, a new NLRP3 Inflammasome Inhibitor with ex vivo cardioprotective effect | 2024 | Francesca Boccato, Simone Gastaldi, Magalì Giordano, Elisabetta Marini, Francesca Spyrakis, Pasquale Pagliaro, Claudia Penna, Massimo Bertinaria | |
| Development of covalent NLRP3 inflammasome inhibitors: chemistry and biological activity | 2019 | Bertinaria Massimo, Gastaldi Simone, Marini Elisabetta, Giorgis Marta | |
| Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation | 2023 | Gastaldi, Simone; Rocca, Carmine; Gianquinto, Eleonora; Granieri, Maria Concetta; Boscaro, Valentina; Blua, Federica; Rolando, Barbara; Marini, Elisabetta; Gallicchio, Margherita; De Bartolo, Anna; Romeo, Naomi; Mazza, Rosa; Fedele, Francesco; Pagliaro, Pasquale; Penna, Claudia; Spyrakis, Francesca; Bertinaria, Massimo; Angelone, Tommaso | |
| Discovery of a septin-4 covalent binder with antimetastatic activity in a mouse model of melanoma | 2024 | Blua F.; Monge C.; Gastaldi S.; Clemente N.; Pizzimenti S.; Lazzarato L.; Senetta R.; Vittorio S.; Gigliotti C.L.; Boggio E.; Dianzani U.; Vistoli G.; Altomare A.A.; Aldini G.; Dianzani C.; Marini E.; Bertinaria M. | |
| EVALUATION OF THE ANTIPYROPTOTIC ACTIVITY OF NEW INFLAMMASOME INHIBITORS | 2021 | Boscaro Valentina, Gastaldi Simone, Bertinaria Massimo, Gallicchio Margherita | |
| In silico study of NLRP3: towards selective inhibition with small molecules | 2019 | Alejandro Gómez García, Simone Gastaldi, Giulia Fumero, Massimo Bertinaria, José Luis Medina Franco | |
| In the search for new NLRP3 inhibitors: chemical modulation of the 1-(piperidin-4-yl)-1,3-dihydro-2 Hbenzo[d]imidazole-2-one scaffold | 2021 | Simone Gastaldi, Valentina Boscaro, Eleonora Gianquinto, Christina F. Sandall, Marta Giorgis, Elisabetta Marini, Federica Blua, Margherita Gallicchio, Francesca Spyrakis, Justin A. MacDonald, Massimo Bertinaria | |
| Inflammasome Biology Fundamentals, Role in Disease States, and Therapeutic Opportunities | 2022 | Massimo Bertinaria, Simone Gastaldi, Elisabetta Marini | |
| Inhibition of NLRP3 ATPase activity: a new strategy to fight chronic inflammatory diseases | 2019 | Simone Gastaldi, Federica Blua, Marta Giorgis, Elisabetta Marini, Massimo Bertinaria | |
| Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein | 2022 | Marini, Elisabetta; Marino, Marco; Gionfriddo, Giulia; Maione, Federica; Pandini, Marta; Oddo, Daniele; Giorgis, Marta; Rolando, Barbara; Blua, Federica; Gastaldi, Simone; Marchiò, Serena; Kovachka, Sandra; Spyrakis, Francesca; Gianquinto, Eleonora; Di Nicolantonio, Federica; Bertinaria, Massimo | |
| New anti-inflammatory agents for the treatment of chronic inflammatory diseases In the search of NLRP3 inflammasome inhibitors | 2022 | - | |
| New inhibitors of NLRP3 inflammasome activation: pharmacological characterization in differentiated THP-1. | 2022 | Valentina Boscaro, Simone Gastaldi, Federica Blua, Massimo Bertinaria, Margherita Gallicchio | |
| NEW NON-COVALENT INHIBITORS OF NLRP3 INFLAMMASOME ATPASE ACTIVITY | 2019 | Gastaldi, S; Marino, M.; Giorgis, M.; Marini, E.; Boscaro, V.; Gallicchio, M.; Bertinaria, M. | |
| NLRP3 INFLAMMASOME-inhibiting compounds and the use thereof | 2022 | Blandizzi Corrado, Pellegrini Carolina, Fornai Matteo, Antonioli Luca, Colucci Rocchina, Bertinaria Massimo, Marini Elisabetta, Boscaro Valentina, Gastaldi Simone, Cocco Mattia | |
| Pharmacological characterization of new NLRP3 inflammasome inhibitors. | 2019 | Valentina Boscaro, Simone Gastaldi, Marco Marino, Marta Giorgis, Elisabetta Marini, Massimo Bertinaria, Margherita Gallicchio |