Echografic evaluation of the artery wall represents an easy and cheap non-invasive method useful to detect the thickness change both of the aorta and the carotid artery. AIM of the study is to test the medio-intimal thickness of the aorta (aIMT) and carotid (cIMT) artery in an hyperlipidemic cohort of children and their affected parents. METHODS: 54 children, 15 FCHL (age 9.2+4.5 yrs), 21 FH (age 9.4+4.5 yrs), 18 unaffected siblings as controls, (age 8.3+3.5yrs) and 28 adults (15 FCHL and 13 FH age 41.5+6.2 yrs) were recruited among dislipemic patients affering to our clinic. FH diagnosis was based on molecular analysis and/or clinical/biochemical data, while FCHL diagnosis was made on the basis of CT, Tg and apoB increased levels, as well as parental phenotype. All patients were submitted to high resolution B-mode ultrasonographic technique using echotomographic system (ATL Apogee 800 plus, USA) and a 7.5 to 10 MHz linear transducer. RESULTS: the mean values of TC, LDL-C, apoB and Tg in FCHL children were respectively 209+29, 135+26, 100+18, 104+63 and in their parents were 252+37, 169+39, 125+18, 191+100 (mg%sd); in FH children the levels resulted 285+52, 217+51, 138+25, 97+37 and in their parents 385+84, 293+90, 168+98 (mg%sd). Children controls shows CT 173+14, LDL-C 100+11, apoB 77+12, Tg 61+21 (mg%sd). The aIMT was respectively 0.53+0.1, 0.51+0.1, 0.45+0.1 mm in FCHL, FH and controls children. The cIMT resulted 0.51+0.1, 0.50+0.1, 0.42+0.1 mm in FCHL, FH and controls children, while FCHL and FH adults patients presented 0.59+0.1 and 0.73+0.18 mm. respectively. CONCLUSION: as atherosclerosis starts since paediatric age and as the present results demonstrate an increased significant intimal-media thickness, it appears useful to detect all hyperlipidemic children and to follow them with this useful technique.

Artery wall B-mode ultrasound measurment in hyperlipidemic children. / Guardamagna O; Rolfo E; Bobbio A; Rabbone I; Mercadante G; Bondone C.. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 12(4)(2002), pp. 228-228. ((Intervento presentato al convegno XVI Congresso Società Italiana Studio Aterosclerosi tenutosi a Chieti nel 27-30 novembre 2002.

Artery wall B-mode ultrasound measurment in hyperlipidemic children.

GUARDAMAGNA, Ornella;BONDONE, claudia
2002

Abstract

Echografic evaluation of the artery wall represents an easy and cheap non-invasive method useful to detect the thickness change both of the aorta and the carotid artery. AIM of the study is to test the medio-intimal thickness of the aorta (aIMT) and carotid (cIMT) artery in an hyperlipidemic cohort of children and their affected parents. METHODS: 54 children, 15 FCHL (age 9.2+4.5 yrs), 21 FH (age 9.4+4.5 yrs), 18 unaffected siblings as controls, (age 8.3+3.5yrs) and 28 adults (15 FCHL and 13 FH age 41.5+6.2 yrs) were recruited among dislipemic patients affering to our clinic. FH diagnosis was based on molecular analysis and/or clinical/biochemical data, while FCHL diagnosis was made on the basis of CT, Tg and apoB increased levels, as well as parental phenotype. All patients were submitted to high resolution B-mode ultrasonographic technique using echotomographic system (ATL Apogee 800 plus, USA) and a 7.5 to 10 MHz linear transducer. RESULTS: the mean values of TC, LDL-C, apoB and Tg in FCHL children were respectively 209+29, 135+26, 100+18, 104+63 and in their parents were 252+37, 169+39, 125+18, 191+100 (mg%sd); in FH children the levels resulted 285+52, 217+51, 138+25, 97+37 and in their parents 385+84, 293+90, 168+98 (mg%sd). Children controls shows CT 173+14, LDL-C 100+11, apoB 77+12, Tg 61+21 (mg%sd). The aIMT was respectively 0.53+0.1, 0.51+0.1, 0.45+0.1 mm in FCHL, FH and controls children. The cIMT resulted 0.51+0.1, 0.50+0.1, 0.42+0.1 mm in FCHL, FH and controls children, while FCHL and FH adults patients presented 0.59+0.1 and 0.73+0.18 mm. respectively. CONCLUSION: as atherosclerosis starts since paediatric age and as the present results demonstrate an increased significant intimal-media thickness, it appears useful to detect all hyperlipidemic children and to follow them with this useful technique.
XVI Congresso Società Italiana Studio Aterosclerosi
Chieti
27-30 novembre 2002
12(4)
228
228
FH; FCHL; Intima media thickness; atherosclersosis; preclinical signs
Guardamagna O; Rolfo E; Bobbio A; Rabbone I; Mercadante G; Bondone C.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/122291
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