To describe the contemporary features of coagulase-negative staphylococcal (CoNS) prosthetic valve endocarditis (PVE).Observational study of prospectively collected data from a multinational cohort of patients with infective endocarditis. Patients with CoNS PVE were compared to patients with Staphylococcus aureus and viridans streptococcal (VGS) PVE.The International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) is a contemporary cohort of patients with infective endocarditis from 61 centres in 28 countries.Adult patients in the ICE-PCS with definite PVE and no history of injecting drug use from June 2000 to August 2005 were included.None.Heart failure, intracardiac abscess, death.CoNS caused 16\% (n = 86) of 537 cases of definite non-injecting drug use-associated PVE. Nearly one-half (n = 33/69, 48\%) of patients with CoNS PVE presented between 60 days and 365 days of valve implantation. The rate of intracardiac abscess was significantly higher in patients with CoNS PVE (38\%) than in patients with either S aureus (23\%, p = 0.03) or VGS (20\%, p = 0.05) PVE. The rate of abscess was particularly high in early (50\%) and intermediate (52\%) CoNS PVE. In-hospital mortality was 24\% for CoNS PVE, 36\% for S aureus PVE (p = 0.09) and 9.1\% for VGS PVE (p = 0.08). Meticillin resistance was present in 68\% of CoNS strains.Nearly one-half of CoNS PVE cases occur between 60 days and 365 days of prosthetic valve implantation. CoNS PVE is associated with a high rate of meticillin resistance and significant valvular complications.

Coagulase-negative staphylococcal prosthetic valve endocarditis--a contemporary update based on the International Collaboration on Endocarditis: prospective cohort study.

DE ROSA, Francesco Giuseppe;
2009-01-01

Abstract

To describe the contemporary features of coagulase-negative staphylococcal (CoNS) prosthetic valve endocarditis (PVE).Observational study of prospectively collected data from a multinational cohort of patients with infective endocarditis. Patients with CoNS PVE were compared to patients with Staphylococcus aureus and viridans streptococcal (VGS) PVE.The International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) is a contemporary cohort of patients with infective endocarditis from 61 centres in 28 countries.Adult patients in the ICE-PCS with definite PVE and no history of injecting drug use from June 2000 to August 2005 were included.None.Heart failure, intracardiac abscess, death.CoNS caused 16\% (n = 86) of 537 cases of definite non-injecting drug use-associated PVE. Nearly one-half (n = 33/69, 48\%) of patients with CoNS PVE presented between 60 days and 365 days of valve implantation. The rate of intracardiac abscess was significantly higher in patients with CoNS PVE (38\%) than in patients with either S aureus (23\%, p = 0.03) or VGS (20\%, p = 0.05) PVE. The rate of abscess was particularly high in early (50\%) and intermediate (52\%) CoNS PVE. In-hospital mortality was 24\% for CoNS PVE, 36\% for S aureus PVE (p = 0.09) and 9.1\% for VGS PVE (p = 0.08). Meticillin resistance was present in 68\% of CoNS strains.Nearly one-half of CoNS PVE cases occur between 60 days and 365 days of prosthetic valve implantation. CoNS PVE is associated with a high rate of meticillin resistance and significant valvular complications.
2009
http://dx.doi.org/10.1136/hrt.2008.152975
Aged, Bioprosthesis, Coagulase, Cross Infection; drug therapy/microbiology/mortality, Drug Resistance; Microbial, Endocarditis; Bacterial; drug therapy/microbiology/mortality, Female, Heart Valve Prosthesis, Hospital Mortality, Humans, Male, Middle Aged, Postoperative Complications; drug therapy/microbiology/mortality, Prospective Studies, Prosthesis-Related Infections; drug therapy/microbiology/mortality, Staphylococcal Infections; drug therapy/mortality, Staphylococcus aureus, Statistics; Nonparametric, Time Factors
Chu VH, Miro JM, Hoen B, Cabell CH, Pappas PA, Jones P, Stryjewski ME, Anguera I, Braun S, Muñoz P, Commerford P, Tornos P, Francis J, Oyonarte M, Selton-Suty C, Morris AJ, Habib G, Almirante B, Sexton DJ, Corey GR, Fowler VG Jr; International Collaboration on Endocarditis-Prospective Cohort Study Group. Collaborators: Gordon D, Devi U, Spelman D, van der Meer JT, Kauffman C, Bradley S, Armstrong W, Giannitsioti E, Giamarellou H, Lerakis S, del Rio A, Moreno A, Mestres CA, Pare C, Garcia de la Maria C, Claramonte X, Armero Y, De Lazzario E, Marco F, Gatell JM, Miro JM, Almela M, Azqueta M, Jiménez-Expósito MJ, de Benito N, Ramirez J, Perez N, Almirante B, Fernandez-Hidalgo N, Rodriguez de Vera P, Tornos P, Falcó V, Sidani N, Kanj-Sharara S, Kanafani Z, Raglio A, Goglio A, Gnecchi F, Suter F, Valsecchi G, Rizzi M, Ravasio V, Hoen B, Chirouze C, Giannitsioti E, Leroy J, Plesiat P, Bernard Y, Casey A, Lambert P, Watkin R, Elliott T, Patel M, Dismukes W, Pan A, Caros G, Tribouilloy AB, Goissen T, Delahaye A, Delahaye F, Vandenesch F, Vizzotti C, Nacinovich FM, Marin M, Trivi M, Lombardero M, Cortes C, Casabe JH, Altclas J, Kogan S, Clara L, Sanchez M, Commerford A, Hansa C, Deetlefs E, Ntsekhe M, Commerford P, Wray D, Steed LL, Church P, Cantey R, Morris A, Holland D, Murdoch D, Read K, Raymond N, Lang S, Chambers S, Kotsanas D, Korman TM, Peterson G, Purcell J, Southern PM Jr, Shah M, Bedimo R, Reddy A, Levine D, Dhar G, Hanlon-Feeney A, Hannan M, Kelly S, Wang A, Cabell CH, Woods CW, Sexton DJ, Benjamin D Jr, Corey GR, McDonald JR, Federspiel J, Engemann JJ, Reller LB, Drew L, Caram LB, Stryjewski M, Morpeth S, Lalani T, Fowler V Jr, Chu V, Mazaheri B, Neuerburg C, Naber C, Athan E, Henry M, Harris O, Alestig E, Olaison L, Wikstrom L, Snygg-Martin U, Francis J, Venugopal K, Nair L, Thomas V, Chaiworramukkun J, Pachirat O, Chetchotisakd P, Suwanich T, Kamarulzaman A, Tamin SS, Premru MM, Logar M, Lejko-Zupanc T, Orezzi C, Klein J, Bouza E, Moreno M, Rodríguez-Créixems M, Marín M, Fernández M, Muñoz P, Fernández R, Ramallo V, Raoult D, Thuny F, Habib G, Casalta JP, Fournier PE, Chipigina N, Kirill O, Vinogradova T, Kulichenko VP, Butkevich OM, Lion C, Selton-Suty C, Alla F, Coyard H, Doco-Lecompte T, Iarussi D, Durante-Mangoni E, Ragone E, Dialetto G, Tripodi MF, Utili R, Casillo R, Kumar AS, Sharma G, Dickerman SA, Street A, Eisen DP, Grigg L, Abrutyn E, Michelet C, Tattevin P, Donnio PY, Fortes CQ, Edathodu J, Al-Hegelan M, Font B, Anguera I, Guma JR, Cereceda M, Oyonarte MJ, Mella RM, Garcia P, Jones SB, Ramos AI, Paiva MG, Tranchesi RA, Woon LL, Lum LN, Tan RS, Rees D, Kornecny P, Lawrence R, Dever R, Post J, Jones P, Ryan S, Harkness J, Feneley M, Rubinstein E, Strahilewitz J, Ionac A, Mornos C, Dragulescu S, Forno D, Cecchi E, De Rosa F, Imazio M, Trinchero R, Wiesbauer F, Gattringer R, Rubinstein E, Deans G, Andrasevic AT, Barsic B, Klinar I, Vincelj J, Bukovski S, Krajinovic V.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/122680
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