Polyphenols are naturally occurring molecules with many interesting biological properties (e.g. anti-oxidant, anti-carcinogenic and antibacterial) and it has been reported that they can stimulate the growth of healthy bone cells [1-4]. Their low bioavailability and short half life prevent an effective application as natural therapeutic agents [1]. Surface functionalization of biomaterials with biologically active molecules is a challenging and versatile tool for localized delivery, improved bioavailability and efficacy. Bioactive glasses and glass ceramics are widely studied in the bone reconstruction and regeneration fields because they are able to chemically bond to bone (development of an hydroxyapatite layer) and to stimulate osteoblasts (ion release). The surface reactivity of these materials can be employed for the grafting of biomolecules and drugs to exposed OH groups or by the adsorption of the same molecules in the silica gel layer developed in aqueous media. The combination of polyphenols and bioactive glasses and glass ceramics can be employed for the localized and controlled delivery of these molecules, improving their stability, bioavailability and efficacy.
Polyphenols grafting to bioactive glasses and glass-ceramics
PRENESTI, Enrico;
2013-01-01
Abstract
Polyphenols are naturally occurring molecules with many interesting biological properties (e.g. anti-oxidant, anti-carcinogenic and antibacterial) and it has been reported that they can stimulate the growth of healthy bone cells [1-4]. Their low bioavailability and short half life prevent an effective application as natural therapeutic agents [1]. Surface functionalization of biomaterials with biologically active molecules is a challenging and versatile tool for localized delivery, improved bioavailability and efficacy. Bioactive glasses and glass ceramics are widely studied in the bone reconstruction and regeneration fields because they are able to chemically bond to bone (development of an hydroxyapatite layer) and to stimulate osteoblasts (ion release). The surface reactivity of these materials can be employed for the grafting of biomolecules and drugs to exposed OH groups or by the adsorption of the same molecules in the silica gel layer developed in aqueous media. The combination of polyphenols and bioactive glasses and glass ceramics can be employed for the localized and controlled delivery of these molecules, improving their stability, bioavailability and efficacy.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
