Objective: To assert if whether or not the Sex Reassignment Surgery (SRS) might provoke some indirect effects on the cerebral activity of MtoF transsexuals. Methods: We recruited 15 transsexuals MtoF. The average age was 35 years (23–63). The experiment has been carried out in all patients 6 months before and 6 months after the SRS. The hormonal therapy was discontinued at least 4 weeks before the preoperative recordings, in order to avoid a bias. 20 heterosexual healthy right-handed volunteers (10 male, 10 female), with an average age of 35 years, were also recruited. The emotional ERPs were achieved while the subjects were watching slides extracted from the International Affective Picture System. 60 pictures, divided in two series with positive/neutral and negative/neutral valence were dispensed in random series to the subjects. The subject was given the task of tapping the remote control with the fi nger while watching pleasant or unpleasant pictures. The parameters considered in our analysis were the area below the P300 wave, the amplitude and his latency. The P300 was fi nally compared between transsexual patients, before and after SRS and control groups. Results: Our analysis pointed out that female’s P300 was characterized by a larger latency, amplitude and area, comparing to the male’s one. This pattern was evidenced in response to pleasant and unpleasant pictures (p < 0,01). The MtoF transsexuals were characterized in response to positive or neutral stimuli by an augmentation of all the P300 parameters evaluated in the postoperative recordings, (p < 0,01). We didn’t found any difference (p > 0,05) concerning the parameters of the P300 wave in response to the neutral pictures. Conclusion: Transsexuals, who underwent a SRS as well as a genital surgical feminization, tend to assume female cerebral features. Our paperwork underlines the benefi cial effects of the SRS to the patients, who react to the genital surgery conversion with a cerebral feminization.

CEREBRAL MODIFICATION IN MTOF TRANSSEXUALS AFTER THE SEX REASSIGNMENT SURGERY: A NEUROPHYSIOLOGICAL STUDY BASED ON AN EMOTIONAL P300

ROLLE, Luigi;FALCONE, MARCO;VIGHETTI, Sergio;CERUTI, Carlo;FONTANA, Dario
2012

Abstract

Objective: To assert if whether or not the Sex Reassignment Surgery (SRS) might provoke some indirect effects on the cerebral activity of MtoF transsexuals. Methods: We recruited 15 transsexuals MtoF. The average age was 35 years (23–63). The experiment has been carried out in all patients 6 months before and 6 months after the SRS. The hormonal therapy was discontinued at least 4 weeks before the preoperative recordings, in order to avoid a bias. 20 heterosexual healthy right-handed volunteers (10 male, 10 female), with an average age of 35 years, were also recruited. The emotional ERPs were achieved while the subjects were watching slides extracted from the International Affective Picture System. 60 pictures, divided in two series with positive/neutral and negative/neutral valence were dispensed in random series to the subjects. The subject was given the task of tapping the remote control with the fi nger while watching pleasant or unpleasant pictures. The parameters considered in our analysis were the area below the P300 wave, the amplitude and his latency. The P300 was fi nally compared between transsexual patients, before and after SRS and control groups. Results: Our analysis pointed out that female’s P300 was characterized by a larger latency, amplitude and area, comparing to the male’s one. This pattern was evidenced in response to pleasant and unpleasant pictures (p < 0,01). The MtoF transsexuals were characterized in response to positive or neutral stimuli by an augmentation of all the P300 parameters evaluated in the postoperative recordings, (p < 0,01). We didn’t found any difference (p > 0,05) concerning the parameters of the P300 wave in response to the neutral pictures. Conclusion: Transsexuals, who underwent a SRS as well as a genital surgical feminization, tend to assume female cerebral features. Our paperwork underlines the benefi cial effects of the SRS to the patients, who react to the genital surgery conversion with a cerebral feminization.
XV ESSM Congress
Amsterdam
dic 2012
9
s 5
361
361
Rolle L; Molo MT; Falcone M; Vighetti S; Timpano M; Ceruti C; Sedigh O; Galletto E; Preto M; Fontana D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/140241
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