In this study we tested the IWG-MRT prognostic score in a retrospective group of 204 World Health Organization-defined PV patients, diagnosed from 1974 to 2013 by a single Italian haematological centre (Turin). The overall survival at 10 years was 85.3% (95%CI:77.6-90.5) and the cumulative incidence of death due to PD (leukemic transformation or evolution in myelofibrosis) adjusted for competitive risk event was 9.8% (95%IC: 4.5-15.0). The prognostic model displayed discrimination between high-risk (n= 91; 10-year survival 68.3%; vs low-risk HR 8.48; 95%CI: 1.94-37.16), intermediate-risk (n= 49; 10-year survival 94.7%; vs low-risk HR 3.23; 95%CI: 0.62-16.68) and low-risk (n=42; 10-year survival 100%) patient groups. The C-statistic was 0.751. Age was the prognostic factor at highest impact on OS. In conclusion, IWG-MRT prognostic score was confirmed as a good predictor of survival and prognosis. Older age was described with the prognostic factor at highest impact on OS.

In patients with Polycythemia Vera older age is the prognostic factor at highest impact on survival

PICH, Achille;FERRERO, Dario;
2014-01-01

Abstract

In this study we tested the IWG-MRT prognostic score in a retrospective group of 204 World Health Organization-defined PV patients, diagnosed from 1974 to 2013 by a single Italian haematological centre (Turin). The overall survival at 10 years was 85.3% (95%CI:77.6-90.5) and the cumulative incidence of death due to PD (leukemic transformation or evolution in myelofibrosis) adjusted for competitive risk event was 9.8% (95%IC: 4.5-15.0). The prognostic model displayed discrimination between high-risk (n= 91; 10-year survival 68.3%; vs low-risk HR 8.48; 95%CI: 1.94-37.16), intermediate-risk (n= 49; 10-year survival 94.7%; vs low-risk HR 3.23; 95%CI: 0.62-16.68) and low-risk (n=42; 10-year survival 100%) patient groups. The C-statistic was 0.751. Age was the prognostic factor at highest impact on OS. In conclusion, IWG-MRT prognostic score was confirmed as a good predictor of survival and prognosis. Older age was described with the prognostic factor at highest impact on OS.
2014
19th Congress of the European Hematology Association
Milan, Italy
June 12-15, 2014
99(s1)
673
674
http://www.haematologica.org/content/99/supplement_1
Polycythemia vera; Age; Prognosis
Benevolo, G; Nicolino, B; Crisà, E; Pregno, P; Evangelista, A; Pirillo, F; D’Antico, S; Pich, Achille; Ferrero, Dario; Vitolo, U....espandi
File in questo prodotto:
File Dimensione Formato  
Benevolo et al EHA PV 2014_post_print.pdf

Accesso aperto

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 168.6 kB
Formato Adobe PDF
168.6 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/148685
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact