In patients with Polycythemia Vera older age is the prognostic factor at highest impact on survival

In this study we tested the IWG-MRT prognostic score in a retrospective group of 204 World Health Organization-defined PV patients, diagnosed from 1974 to 2013 by a single Italian haematological centre (Turin). The overall survival at 10 years was 85.3% (95%CI:77.6-90.5) and the cumulative incidence of death due to PD (leukemic transformation or evolution in myelofibrosis) adjusted for competitive risk event was 9.8% (95%IC: 4.5-15.0). The prognostic model displayed discrimination between high-risk (n= 91; 10-year survival 68.3%; vs low-risk HR 8.48; 95%CI: 1.94-37.16), intermediate-risk (n= 49; 10-year survival 94.7%; vs low-risk HR 3.23; 95%CI: 0.62-16.68) and low-risk (n=42; 10-year survival 100%) patient groups. The C-statistic was 0.751. Age was the prognostic factor at highest impact on OS. In conclusion, IWG-MRT prognostic score was confirmed as a good predictor of survival and prognosis. Older age was described with the prognostic factor at highest impact on OS.