Several environmental substances (synthetic or natural) are able to impact endocrine function (endocrine disrupting chemicals, EDCs) and, therefore, they may have long-term consequences, especially if exposure occurs during embryonic development. Most of EDCs are agonists or antagonists of androgen or estrogen receptors, therefore they may interfere with brain and behavior sexual differentiation. We present here data collected in our laboratory on two animal models: the mouse and the Japanese quail. In the quail, we investigated the effect of several EDCs [diethylstilbestrol (DES), genistein or ethylene,1,1-dichloro-2,2-bis-p-chlorophenyl (DDE)] administered in eggs on the differentiation of male sexual behavior and of the parvocellular sexually dimorphic vasotocin system. In the mouse we investigated the effects of perinatal exposure to bisphenol A (BPA) on the sexual differentiation of NO producing system and of the kisspeptin system. We investigated also the organizational effects of these EDCs on sexual, social, and explorative behaviors. Our data suggest that precocious exposure to EDCs through maternal administration (in mice) or in egg deposition (in quail) may permanently alter some sexually dimorphic circuits and influence in a gender-oriented way some behaviors. In particular, the timing of exposure to EDCs is a critical factor, such that the effects of a particular EDC will vary over the lifecycle of the animal as well as across species and phyla. Therefore, exposure to the estrogenic chemicals during embryonic development has consequences beyond impaired function of the reproductive axis. This makes it very challenging to evaluate the short and long-term effects of EDCs. These compounds are therefore a third player within the nervous system and the evolutionary implications of having them in the normal food supply for certain human populations (i.e. phytoestrogen derivatives from soy), as well as for wild and farm animals should stimulate a wide discussion about their beneficial or adverse role.

Environment and brain sexual differentiation: what role for endocrine disrupters?

PANZICA, Giancarlo;GOTTI, STEFANO
2012

Abstract

Several environmental substances (synthetic or natural) are able to impact endocrine function (endocrine disrupting chemicals, EDCs) and, therefore, they may have long-term consequences, especially if exposure occurs during embryonic development. Most of EDCs are agonists or antagonists of androgen or estrogen receptors, therefore they may interfere with brain and behavior sexual differentiation. We present here data collected in our laboratory on two animal models: the mouse and the Japanese quail. In the quail, we investigated the effect of several EDCs [diethylstilbestrol (DES), genistein or ethylene,1,1-dichloro-2,2-bis-p-chlorophenyl (DDE)] administered in eggs on the differentiation of male sexual behavior and of the parvocellular sexually dimorphic vasotocin system. In the mouse we investigated the effects of perinatal exposure to bisphenol A (BPA) on the sexual differentiation of NO producing system and of the kisspeptin system. We investigated also the organizational effects of these EDCs on sexual, social, and explorative behaviors. Our data suggest that precocious exposure to EDCs through maternal administration (in mice) or in egg deposition (in quail) may permanently alter some sexually dimorphic circuits and influence in a gender-oriented way some behaviors. In particular, the timing of exposure to EDCs is a critical factor, such that the effects of a particular EDC will vary over the lifecycle of the animal as well as across species and phyla. Therefore, exposure to the estrogenic chemicals during embryonic development has consequences beyond impaired function of the reproductive axis. This makes it very challenging to evaluate the short and long-term effects of EDCs. These compounds are therefore a third player within the nervous system and the evolutionary implications of having them in the normal food supply for certain human populations (i.e. phytoestrogen derivatives from soy), as well as for wild and farm animals should stimulate a wide discussion about their beneficial or adverse role.
FENS (8th)
Barcelona
14-18 luglio
Abstract Number: 3380
3380
3380
http://ebooks.meetingxpert.net/fens/#/192
Panzica GianCarlo; Gotti Stefano
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/151882
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact