Introduction: Dyslipidemias are one of the major risk factors for atherogenesis and the determination of lipoprotein(a) [Lp(a)] is one of the emerging component to evaluate accurately the cardiovascular risk. HyperLp(a) is often related to hypercholesterolemia but few studies about isolated hyperLp(a) have been reported in pediatrics. Objective: The first aim is to identify patients with isolated hyperLp(a) in children with a familial history positive for cardiovascular events (CVD+) and/or dyslipidemia. The second is to evaluate the correlation between familial CVD and Lp(a) levels. Methods: In 53 subjects (24 female, 29 male), 6-18 years, Lp(a) level, lipid profile and a 2-generation genealogic tree to detect CVD were evaluated according to standard methods. Children with isolated hyperLp(a) (> 30 mg/dL) were selected. Lp(a) levels were stratified according to onset age, number and type of CVD in children kindreds. CVD occurring < 55 years in males and <65 years in females were considered precocious events (pCVD). Results: Children showed a highly skewed distribution of Lp(a) concentrations [75 (31-261,8) mg/dl]. 37 patients (69.8%) resulted CVD+ and 28 (52.8%) pCVD+, without significant differences in lipid profile and Lp(a) levels. We observed the highest Lp(a) levels in children with a family history for both myocardial infarctions and strokes [103,95 (57,1-261,8) mg/dl]. Moreover patients with relatives and/or grandparents who had both precocious and late events presented an increase of Lp(a) [117,2 (36,6-261,8)mg/dl] but not statistically relevant. Conclusion: This study showed the high frequency of familiar CVD events, in particular pCVD ones, in children with isolated hyperLp(a). Furthermore we observed a relation between Lp(a) levels and the type of CVD in their families. Long-term follow-up studies are needed to determine whether isolated hyperLp(a) levels in children are associated with increased later cardiovascular risk.
Isolated Hyperlipoprotein(a) in children with familial cardiovascular events.
ABELLO, Francesca;GUARDAMAGNA, Ornella
2011-01-01
Abstract
Introduction: Dyslipidemias are one of the major risk factors for atherogenesis and the determination of lipoprotein(a) [Lp(a)] is one of the emerging component to evaluate accurately the cardiovascular risk. HyperLp(a) is often related to hypercholesterolemia but few studies about isolated hyperLp(a) have been reported in pediatrics. Objective: The first aim is to identify patients with isolated hyperLp(a) in children with a familial history positive for cardiovascular events (CVD+) and/or dyslipidemia. The second is to evaluate the correlation between familial CVD and Lp(a) levels. Methods: In 53 subjects (24 female, 29 male), 6-18 years, Lp(a) level, lipid profile and a 2-generation genealogic tree to detect CVD were evaluated according to standard methods. Children with isolated hyperLp(a) (> 30 mg/dL) were selected. Lp(a) levels were stratified according to onset age, number and type of CVD in children kindreds. CVD occurring < 55 years in males and <65 years in females were considered precocious events (pCVD). Results: Children showed a highly skewed distribution of Lp(a) concentrations [75 (31-261,8) mg/dl]. 37 patients (69.8%) resulted CVD+ and 28 (52.8%) pCVD+, without significant differences in lipid profile and Lp(a) levels. We observed the highest Lp(a) levels in children with a family history for both myocardial infarctions and strokes [103,95 (57,1-261,8) mg/dl]. Moreover patients with relatives and/or grandparents who had both precocious and late events presented an increase of Lp(a) [117,2 (36,6-261,8)mg/dl] but not statistically relevant. Conclusion: This study showed the high frequency of familiar CVD events, in particular pCVD ones, in children with isolated hyperLp(a). Furthermore we observed a relation between Lp(a) levels and the type of CVD in their families. Long-term follow-up studies are needed to determine whether isolated hyperLp(a) levels in children are associated with increased later cardiovascular risk.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
