PERIPHERAL NERVE INJURY: ANALYSIS OF BIOMOLECULAR CHANGES IN NEURONS AND COMPATIBILITY OF CHITOSAN FOR PERIPHERAL NERVE REGENERATION

In the last years, the regenerative capacity of the peripheral nervous system after injury and nerve repair surgical techniques have been the focus of many studies. Peripheral nerve trauma or injuries may lead to sensory or motor function deficits if not properly treated. To improve peripheral nerve regeneration the surgical approaches have matched the new biomedical strategies such as new devices and the induction of specific factors to enhance the endogenous mechanisms of recovery. All this has been possible thanks to the more in-depth study of biomolecular mechanisms that promote nerve regeneration. The aim of this study was twofold: i) to analyze molecular changes in the cellular body of motor and sensory neurons after peripheral nerve injury; ii) to evaluate the compatibility of a chitosan conduit for peripheral nerve repair and regeneration.