In the last years, the regenerative capacity of the peripheral nervous system after injury and nerve repair surgical techniques have been the focus of many studies. Peripheral nerve trauma or injuries may lead to sensory or motor function deficits if not properly treated. To improve peripheral nerve regeneration the surgical approaches have matched the new biomedical strategies such as new devices and the induction of specific factors to enhance the endogenous mechanisms of recovery. All this has been possible thanks to the more in-depth study of biomolecular mechanisms that promote nerve regeneration. The aim of this study was twofold: i) to analyze molecular changes in the cellular body of motor and sensory neurons after peripheral nerve injury; ii) to evaluate the compatibility of a chitosan conduit for peripheral nerve repair and regeneration.

PERIPHERAL NERVE INJURY: ANALYSIS OF BIOMOLECULAR CHANGES IN NEURONS AND COMPATIBILITY OF CHITOSAN FOR PERIPHERAL NERVE REGENERATION

PASCAL, DAVIDE;RONCHI, GIULIA;FREGNAN, Federica;GAMBAROTTA, Giovanna;RAIMONDO, Stefania;GEUNA, Stefano
2014

Abstract

In the last years, the regenerative capacity of the peripheral nervous system after injury and nerve repair surgical techniques have been the focus of many studies. Peripheral nerve trauma or injuries may lead to sensory or motor function deficits if not properly treated. To improve peripheral nerve regeneration the surgical approaches have matched the new biomedical strategies such as new devices and the induction of specific factors to enhance the endogenous mechanisms of recovery. All this has been possible thanks to the more in-depth study of biomolecular mechanisms that promote nerve regeneration. The aim of this study was twofold: i) to analyze molecular changes in the cellular body of motor and sensory neurons after peripheral nerve injury; ii) to evaluate the compatibility of a chitosan conduit for peripheral nerve repair and regeneration.
9th FENS Forum of Neuroscience
Milan
5-9 july 2014
Sensory and motor systems - Motor neurons and muscle
V
2787
2787
http://fens2014.neurosciences.asso.fr/
Davide Pascal; Giulia Ronchi; Andrea Iannello; Federica Fregnan; Giovanna Gambarotta; Stefania Raimondo; Stefano Geuna
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/153633
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