Aims: Coronary Artery Disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, consequently being appraised in the most common used risk score. Our meta-analysis aims to clarify the association of CAD on mid-term survival in patients undergoing TAVI. Methods and results: A systematic literature review was performed looking for studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 37% to 51% of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. Follow-up time was 452 (357-585) days. After a median follow up of 452 days (357-585) 24% of patients (19-33) died, and 23 (14- 32) for cardiovascular death which was mentioned only in three works At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, Confidence Interval, 0.67-1.50). Conclusion: CAD does not affect mid-term TAVI outcome, and this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis.

Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: a meta-analysis of adjusted observational results / F. D'Ascenzo; F. Conrotto; F. Giordana; C. Moretti; M. D'Amico; C. Tamburino; S. Vicentini; S. Marra; F. Gaita; M. Rinaldi. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - STAMPA. - 34 ( Abstract Supplement )(2013), pp. 989-989. ((Intervento presentato al convegno Esc Congress 2013 tenutosi a Amsterdam nel 31/08/2013-04/09/2013.

Mid-term prognostic value of coronary artery disease in patients undergoing transcatheter aortic valve implantation: a meta-analysis of adjusted observational results

D'ASCENZO, FABRIZIO;GIORDANA, Francesca;VICENTINI, Silvia;GAITA, Fiorenzo;RINALDI, Mauro
2013

Abstract

Aims: Coronary Artery Disease (CAD) negatively affects prognosis in patients undergoing surgical aortic valve replacement, consequently being appraised in the most common used risk score. Our meta-analysis aims to clarify the association of CAD on mid-term survival in patients undergoing TAVI. Methods and results: A systematic literature review was performed looking for studies reporting multivariate predictors of adverse outcomes in patients undergoing TAVI and pooled, when appropriate, using a random-effect method. 960 citations were first screened and finally 7 studies (2472 patients) were included. Diagnosis of CAD was reported in 37% to 51% of patients and 1169 Edwards SAPIEN and 1303 CoreValve prostheses were implanted. Follow-up time was 452 (357-585) days. After a median follow up of 452 days (357-585) 24% of patients (19-33) died, and 23 (14- 32) for cardiovascular death which was mentioned only in three works At pooled analysis of multivariate approach, diagnosis of coronary artery disease did not increase risk of death (OR 1.0, 95% CI, Confidence Interval, 0.67-1.50). Conclusion: CAD does not affect mid-term TAVI outcome, and this finding should be weighted to accurately evaluate risk and strategies for patients with severe aortic stenosis.
Esc Congress 2013
Amsterdam
31/08/2013-04/09/2013
34 ( Abstract Supplement )
989
989
http://spo.escardio.org/abstract-book/presentation.aspx?id=120110
F. D'Ascenzo; F. Conrotto; F. Giordana; C. Moretti; M. D'Amico; C. Tamburino; S. Vicentini; S. Marra; F. Gaita; M. Rinaldi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/158454
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