Introduction: Diabetic subjects develop diffuse microangiopathy. Previous clinical studies suggest pulmonary microangiopathy as a misdiagnosed aspect of diabetes, manifesting itself as reduced carbon monoxide diffusing capacity (DLCO). DLCO alterations may be associated with lung volumes or forced expiratory volume in 1 second (FEV1) reduction, but these data were not universally confirmed. Aims: Here we present our experience on subjects with type 1 diabetes in assessing lung volumes, pulmonary resistances and diffusion capacity. Materials and Methods: Eighteen caucasian diabetic subjects with type 1 diabetes mellitus (11 males, 7 females; mean age 42,6 years; BMI 25,1Kg/m2), actually non smokers, were recruited from the Diabetology Service of Parma University. Results were compared with an age, BMI and sex-matched normative reference population. Subjects performed a complete pulmonary function test including lung volume, spirometry, plethysmographic evaluation of pulmonary resistances, and DLCO. Predicted values were obtained as previously described by the European Community for Coal and Steel. Comparison beetwen groups required expression of respiratory function test values in confront of predicted values, and done with Student's non-paired t test. Statistical calculations were performed with the SPP 11.04 (Mac OsX) statistical package. Results: DLCO (p=0,013) was significantly reduced in diabetics in confront of controls, and also when corrected for alveolar volume (p=0,004) whereas forced vital capacity (FVC, p=0,415), FEV1 (p=0,090) and PEF (p=0,218) residual volume (p=0,138) and total lung capacity (p=0,428) showed not statistical significant differences between subjects and controls. Conclusions: Spirometric values are preserved in our subjects and, consistently with previous reports, there are significant defects in DLCO. These results confirms that diabetic microangiopathy may play an important role in respiratory function.
Carbon monoxide diffusing capacity in type I diabetes melitus: another side of microangiopathy?
BERGAMASCHI, Enrico;
2007-01-01
Abstract
Introduction: Diabetic subjects develop diffuse microangiopathy. Previous clinical studies suggest pulmonary microangiopathy as a misdiagnosed aspect of diabetes, manifesting itself as reduced carbon monoxide diffusing capacity (DLCO). DLCO alterations may be associated with lung volumes or forced expiratory volume in 1 second (FEV1) reduction, but these data were not universally confirmed. Aims: Here we present our experience on subjects with type 1 diabetes in assessing lung volumes, pulmonary resistances and diffusion capacity. Materials and Methods: Eighteen caucasian diabetic subjects with type 1 diabetes mellitus (11 males, 7 females; mean age 42,6 years; BMI 25,1Kg/m2), actually non smokers, were recruited from the Diabetology Service of Parma University. Results were compared with an age, BMI and sex-matched normative reference population. Subjects performed a complete pulmonary function test including lung volume, spirometry, plethysmographic evaluation of pulmonary resistances, and DLCO. Predicted values were obtained as previously described by the European Community for Coal and Steel. Comparison beetwen groups required expression of respiratory function test values in confront of predicted values, and done with Student's non-paired t test. Statistical calculations were performed with the SPP 11.04 (Mac OsX) statistical package. Results: DLCO (p=0,013) was significantly reduced in diabetics in confront of controls, and also when corrected for alveolar volume (p=0,004) whereas forced vital capacity (FVC, p=0,415), FEV1 (p=0,090) and PEF (p=0,218) residual volume (p=0,138) and total lung capacity (p=0,428) showed not statistical significant differences between subjects and controls. Conclusions: Spirometric values are preserved in our subjects and, consistently with previous reports, there are significant defects in DLCO. These results confirms that diabetic microangiopathy may play an important role in respiratory function.
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