Oat (Avena sativa) is a cereal known since antiquity as a useful grain with abundant nutritional and health benefits. It contains distinct molecular components with high antioxidant activity, such as tocopherols, tocotrienols, and flavanoids. In addition, it is a unique source of avenanthramides, phenolic amides containing anthranilic acid and hydroxycinnamic acid moieties, and endowed with major beneficial health properties because of their antioxidant, anti-inflammatory, and antiproliferative effects. In this review, we report on the biological activities of avenanthramides and their derivatives, including analogs produced in recombinant yeast, with a major focus on the therapeutic potential of these secondary metabolites in the treatment of aging-related human diseases. Moreover, we also present recent advances pointing to avenanthramides as interesting therapeutic candidates for the treatment of cerebral cavernous malformation (CCM) disease, a major cerebrovascular disorder affecting up to 0.5% of the human population. Finally, we highlight the potential of foodomics and redox proteomics approaches in outlining distinctive molecular pathways and redox protein modifications associated with avenanthramide bioactivities in promoting human health and contrasting the onset and progression of various pathologies.

Biological activities, health benefits, and therapeutic properties of avenanthramides: From skin protection to prevention and treatment of cerebrovascular diseases

Perrelli, Andrea;Goitre, Luca;Moglia, Andrea;Retta, Saverio Francesco
Last
2018

Abstract

Oat (Avena sativa) is a cereal known since antiquity as a useful grain with abundant nutritional and health benefits. It contains distinct molecular components with high antioxidant activity, such as tocopherols, tocotrienols, and flavanoids. In addition, it is a unique source of avenanthramides, phenolic amides containing anthranilic acid and hydroxycinnamic acid moieties, and endowed with major beneficial health properties because of their antioxidant, anti-inflammatory, and antiproliferative effects. In this review, we report on the biological activities of avenanthramides and their derivatives, including analogs produced in recombinant yeast, with a major focus on the therapeutic potential of these secondary metabolites in the treatment of aging-related human diseases. Moreover, we also present recent advances pointing to avenanthramides as interesting therapeutic candidates for the treatment of cerebral cavernous malformation (CCM) disease, a major cerebrovascular disorder affecting up to 0.5% of the human population. Finally, we highlight the potential of foodomics and redox proteomics approaches in outlining distinctive molecular pathways and redox protein modifications associated with avenanthramide bioactivities in promoting human health and contrasting the onset and progression of various pathologies.
2018
6015351
1
17
https://www.hindawi.com/journals/omcl/2018/6015351/
Oats, avenanthramides, Tranilast, antioxidants, oxidative stress, inflammation, aging-related diseases, cerebrovascular diseases, cerebral cavernous malformation, oxidative post-translational modifications, foodomics, redox proteomics
Perrelli, Andrea; Goitre, Luca; Salzano, Anna Maria; Moglia, Andrea; Scaloni, Andrea; Retta, Saverio Francesco
File in questo prodotto:
File Dimensione Formato  
2018 Oxid Med Cell Longev - Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides- From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 2.65 MB
Formato Adobe PDF
2.65 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1679471
Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 38
  • ???jsp.display-item.citation.isi??? 30
social impact