Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

Bonanni D.;Daga M.;Oliaro-Bosso S.;Boschi D.;Lolli M. L.;
2019

Abstract

Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.
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http://pubs.rsc.org/en/journals/journal/md
AKR1C3; INHIBITORS; Tetrahydroisoquinoline
Santos A.R.N.; Sheldrake H.M.; Ibrahim A.I.M.; Danta C.C.; Bonanni D.; Daga M.; Oliaro-Bosso S.; Boschi D.; Lolli M.L.; Pors K.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1719859
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