The synthesis and study of the antioxidant and vasodilator properties of a new class of phenols able to release nitric oxide are described. The products were designed through a symbiotic approach using selected phenols and selected nitrooxy and furoxan NO-donors as reference models. The antioxidant activities of the hybrid products were assessed by detecting the 2-thiobarbituric acid reactive substances (TBARS) produced in the ferrous salt/ascorbate-induced autoxidation of lipids present in microsomial membranes of rat hepatocytes. The vasodilator activity was assessed on rat aortic strips precontracted with phenylephrine. Some of the products (13, 35, 37, 60-62, 64) behave principally as vasodilators and others as antioxidants (24, 32, 72), and the two properties are relatively balanced in 19, 41, and 68. Further in vivo studies should clarify whether some of these products may become preclinical candidates for the treatment of cardiovascular disease underpinned by atheroma.

NO-Donor Phenols: A New Class of Products Endowed with Antioxidant and Vasodilator Properties

BOSCHI, Donatella;LAZZARATO, Loretta;CHEGAEV, Konstantin;CENA, Clara;DI STILO, Antonella;GIORGIS, Marta;BERTINARIA, Massimo;FRUTTERO, Roberta;GASCO, Alberto
2006-01-01

Abstract

The synthesis and study of the antioxidant and vasodilator properties of a new class of phenols able to release nitric oxide are described. The products were designed through a symbiotic approach using selected phenols and selected nitrooxy and furoxan NO-donors as reference models. The antioxidant activities of the hybrid products were assessed by detecting the 2-thiobarbituric acid reactive substances (TBARS) produced in the ferrous salt/ascorbate-induced autoxidation of lipids present in microsomial membranes of rat hepatocytes. The vasodilator activity was assessed on rat aortic strips precontracted with phenylephrine. Some of the products (13, 35, 37, 60-62, 64) behave principally as vasodilators and others as antioxidants (24, 32, 72), and the two properties are relatively balanced in 19, 41, and 68. Further in vivo studies should clarify whether some of these products may become preclinical candidates for the treatment of cardiovascular disease underpinned by atheroma.
2006
49
10
2886
2897
http://pubs.acs.org/journals/jmcmar/index.html
NITRIC-OXIDE; OXIDATIVE STRESS
D. BOSCHI; G.C. TRON; L. LAZZARATO; K. CHEGAEV; C. CENA; A. DI STILO; M. GIORGIS; M. BERTINARIA; R. FRUTTERO; A. GASCO
File in questo prodotto:
File Dimensione Formato  
2006_antiossidanti_JMC.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 264.51 kB
Formato Adobe PDF
264.51 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Manuscript_phenoli_jmc.pdf

Accesso aperto

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 890.18 kB
Formato Adobe PDF
890.18 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1731
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 54
  • ???jsp.display-item.citation.isi??? 53
social impact