The serum prostate specific antigen is the most widespread biomarker for prostate disease. Its low specificity for prostatic malignancies is a matter of concern and the reason why new biomarkers for screening purposes are needed. The correlation between altered production of the main steroids and prostate carcinoma (PCa) occurrence is historically known. Purpose of this study is to evaluate the modifications of a comprehensive urinary endogenous steroidal profile (USP) induced by PCa, by multivariate statistical methods.
Prospective evaluation of urinary steroids and prostate carcinoma-induced deviation: preliminary results
Amante, Eleonora;Fiori, Cristian;Alleva, Giorgio;Alladio, Eugenio;Garrou, Diletta;Manfredi, Matteo;Amparore, Daniele;Checcucci, Enrico;Salomone, Alberto;Scarpa, Roberto M;Vincenti, Marco;Porpiglia, Francesco
2021-01-01
Abstract
The serum prostate specific antigen is the most widespread biomarker for prostate disease. Its low specificity for prostatic malignancies is a matter of concern and the reason why new biomarkers for screening purposes are needed. The correlation between altered production of the main steroids and prostate carcinoma (PCa) occurrence is historically known. Purpose of this study is to evaluate the modifications of a comprehensive urinary endogenous steroidal profile (USP) induced by PCa, by multivariate statistical methods.
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