Developmental actions of estradiol in the hypothalamus are well characterized. This hormone generates sex differences in the development of hypothalamic neuronal circuits controlling neu- roendocrine events, feeding, growth, reproduction and behavior. In vitro, estradiol promotes sexually dimorphic effects on hypo- thalamic neuritogenesis. Previous studies have shown that devel- opmental actions of the phytoestrogen genistein result in perma- nent sexually dimorphic effects in some behaviors and neural cir- cuits in vivo.
SEXUALLY DIMORPHIC EFFECT OF GENISTEIN ON HYPOTHALAMIC NEURONAL DIFFERENTIATION IN VITRO
M. Marraudino;A. Farinetti;S. Gotti;G. C. Panzica;
2020-01-01
Abstract
Developmental actions of estradiol in the hypothalamus are well characterized. This hormone generates sex differences in the development of hypothalamic neuronal circuits controlling neu- roendocrine events, feeding, growth, reproduction and behavior. In vitro, estradiol promotes sexually dimorphic effects on hypo- thalamic neuritogenesis. Previous studies have shown that devel- opmental actions of the phytoestrogen genistein result in perma- nent sexually dimorphic effects in some behaviors and neural cir- cuits in vivo.
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