The reliabilityof the use of FPTs through the boundaries of an OU process to model interspikes intervals (ISIs) is investigated by means of a new method inspired to an algorithm that solves the inverse FPT proble. The boundary shape corresponding to experimental ISI is determined when the underthreshold membrane potential behavior is modeled via an OU process with parameters estimated from the data. The values are finally compared with the constant value characterizing the model.

On the relationship between interspikes interval distribution and boundary shape in the Ornstein-Uhlenbeck neuronal model

SACERDOTE, Laura Lea;ZUCCA, CRISTINA
2003

Abstract

The reliabilityof the use of FPTs through the boundaries of an OU process to model interspikes intervals (ISIs) is investigated by means of a new method inspired to an algorithm that solves the inverse FPT proble. The boundary shape corresponding to experimental ISI is determined when the underthreshold membrane potential behavior is modeled via an OU process with parameters estimated from the data. The values are finally compared with the constant value characterizing the model.
ESMTB: Mathematical Modelling & Computing in Biology and Medicine,
Milano
2-6 Luglio 2002
Mathematical Modelling & Computing in Biology and Medicine
Esculapio Capasso Ed.
161
168
Interspikes Intervals; Ornstein Uhlenbeck process; First passage time
Sacerdote L.; Zucca C.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/19752
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