Background: Despite the large number of hospitalized patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, few data are available about risk factors and mortality in subjects with nosocomially acquired respiratory infection of Cor-onavirus Disease 2019 (COVID-19). Methods: We retrospectively evaluated in a multicentric study-during the pre-vaccination era -all patients admitted with confirmed diagnosis of nosocomial COVID-19 (NC). Patients were classified according to provenance: hospital-acquired NC or long-term care (LTC) facilities. Results: Among overall 1047 patients evaluated with COVID-19, 137 had a confirmed diagnosis of NC (13%). 78 (56.9%) patients had hospital-acquired NC and 59 (43%) had LTC NC. Overall mortality was 35.8%, in hospital-acquired NC 24.4%, in LTC NC 50.8% (p < 0.001) (Log Rank test: p Z 0.001). Timing of diagnosis was significantly different between hospital acquired and LTC NC (3.5 vs 10 days, p < 0.001). In multivariate analysis age, intensive-care unit admission, LTC provenance and sepsis were significant predictors of mortality in patients with NC infection. Conclusion: Patients with NC are at higher risk of mortality (especially for LTC NC) and required preventive strategies, early diagnosis, and treatment to avoid COVID-19 cluster. & COPY; 2022 Australasian College for Infection Prevention and Control. Published by Elsevier B.V. All rights reserved.

Predictors of mortality in patients with COVID-19 infection in different health-care settings: A retrospective analysis from a CORACLE study group

Boglione, Lucio;Corcione, Silvia;Shbaklo, Nour;Lupia, Tommaso;Scabini, Silvia;Mornese Pinna, Simone;De Rosa, Francesco Giuseppe
Last
2023-01-01

Abstract

Background: Despite the large number of hospitalized patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, few data are available about risk factors and mortality in subjects with nosocomially acquired respiratory infection of Cor-onavirus Disease 2019 (COVID-19). Methods: We retrospectively evaluated in a multicentric study-during the pre-vaccination era -all patients admitted with confirmed diagnosis of nosocomial COVID-19 (NC). Patients were classified according to provenance: hospital-acquired NC or long-term care (LTC) facilities. Results: Among overall 1047 patients evaluated with COVID-19, 137 had a confirmed diagnosis of NC (13%). 78 (56.9%) patients had hospital-acquired NC and 59 (43%) had LTC NC. Overall mortality was 35.8%, in hospital-acquired NC 24.4%, in LTC NC 50.8% (p < 0.001) (Log Rank test: p Z 0.001). Timing of diagnosis was significantly different between hospital acquired and LTC NC (3.5 vs 10 days, p < 0.001). In multivariate analysis age, intensive-care unit admission, LTC provenance and sepsis were significant predictors of mortality in patients with NC infection. Conclusion: Patients with NC are at higher risk of mortality (especially for LTC NC) and required preventive strategies, early diagnosis, and treatment to avoid COVID-19 cluster. & COPY; 2022 Australasian College for Infection Prevention and Control. Published by Elsevier B.V. All rights reserved.
2023
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COVID-19; Hospital infection; Long-term care; Mortality; Nosocomial; SARS-CoV-2
Boglione, Lucio; Corcione, Silvia; Shbaklo, Nour; Lupia, Tommaso; Scabini, Silvia; Mornese Pinna, Simone; Borrè, Silvio; De Rosa, Francesco Giuseppe...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1992433
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