Peptide nucleic acids (PNAs) are artificial oligonucleotide mimetics that bind DNA and RNA and are promising tools for gene targeting and nucleic acid sensing. In this work, modified thieno[3,4-d]pyrimidine nucleobases were investigated in PNA chemistry to explore new functional and fluorescent properties, while lipophilic monomers are being developed to improve overall PNA stability.
Functional nucleobases and monomers in PNA chemistry.
Paolo BoninoFirst
;Francesca Cardano;Andrea Fin
Last
2026-01-01
Abstract
Peptide nucleic acids (PNAs) are artificial oligonucleotide mimetics that bind DNA and RNA and are promising tools for gene targeting and nucleic acid sensing. In this work, modified thieno[3,4-d]pyrimidine nucleobases were investigated in PNA chemistry to explore new functional and fluorescent properties, while lipophilic monomers are being developed to improve overall PNA stability.
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