A composition for in vitro use as a culture medium or in vivo use as a pharmaceutical composition or a medical device, capable of accelerating the differentiation of stem cells into cells with a chondrocytic phenotype and of restoring the original trophism of chondrocytes, is described. The composition comprises, in combination, at least one proteolytic enzyme, at least one growth factor and at least one from a sugar, an amino acid, a vitamin factor, a vitamin, a nucleotide and a nucleoside, in a physiologically acceptable carrier or diluent. A method of differentiating stem cells in cells having a chondrocytic phenotype, the cells obtained by the method and their uses, for example in human or animal cell therapy, for example by CBMP (Cellular Based Medicinal products) are also described

A culture medium and pharmaceutical composition for regenerating cartilage tissue, a method, uses and products related thereto

PONZETTO, Antonio;CAVALLO, Giovanni;PESCARMONA, Gianpiero;DENYSENKO, Tetyana;ROOS, Maria Augusta;
2007

Abstract

A composition for in vitro use as a culture medium or in vivo use as a pharmaceutical composition or a medical device, capable of accelerating the differentiation of stem cells into cells with a chondrocytic phenotype and of restoring the original trophism of chondrocytes, is described. The composition comprises, in combination, at least one proteolytic enzyme, at least one growth factor and at least one from a sugar, an amino acid, a vitamin factor, a vitamin, a nucleotide and a nucleoside, in a physiologically acceptable carrier or diluent. A method of differentiating stem cells in cells having a chondrocytic phenotype, the cells obtained by the method and their uses, for example in human or animal cell therapy, for example by CBMP (Cellular Based Medicinal products) are also described
WO/2007/119213
UNI DEGLI STUDI DI TORINO (IT); Gennero Luisa (It); Ponzetto Antonio (It); De Vivo Enrico (It); Contu Luciano (It); Morra Emanuella (It)
http://www.wipo.int/pctdb/en/wo.jsp?WO=2007119213
stem cells; adult pluripotent stem cells; chondrocytes phenotype; proteolytic enzymes; sugar; an amino acid; a vitamin factor; vitamins; nucleotides; nucleosides
GENNERO L; PONZETTO A; DE VIVO E; CONTU L; MORRA E; CESANO C; CAVALLO G; CICERO G; PESCARMONA GP; DENYSENKO T; ROOS MA; SARA M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/27215
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