Multitarget drugs: The title compounds represent the first class of dual-action drugs with 5-LO inhibition and NO-dependent activities. They block leukotriene B4 production with potencies near that of zileuton and are capable of relaxing rat tracheal rings and rat aorta strips through a NO-mediated mechanism. Some compounds also show anti-inflammatory activity in carrageenan- induced rat paw edema.

Multitarget Drugs: Synthesis and Preliminary Pharmacological Characterization of Zileuton Analogues Endowed with Dual 5-LO Inhibitor and NO-Dependent Activities

BOSCHI, Donatella;GIORGIS, Marta;CENA, Clara;DI STILO, Antonella;FRUTTERO, Roberta;GASCO, Alberto
2010-01-01

Abstract

Multitarget drugs: The title compounds represent the first class of dual-action drugs with 5-LO inhibition and NO-dependent activities. They block leukotriene B4 production with potencies near that of zileuton and are capable of relaxing rat tracheal rings and rat aorta strips through a NO-mediated mechanism. Some compounds also show anti-inflammatory activity in carrageenan- induced rat paw edema.
2010
5
9
1444
1449
http://onlinelibrary.wiley.com/doi/10.1002/cmdc.201000198/abstract
5-LO inhibitors; drug design; inflammation; nitric oxide donors; zileuton
Donatella Boschi; Marta Giorgis; Clara Cena; Naveen Chandra Talniya; Antonella Di Stilo; Giuseppina Morini; Gabriella Coruzzi; Elena Guaita; Roberta F...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/76276
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