Sfoglia per Autore
The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia
2021-01-01 Gaidano V.; Houshmand M.; Vitale N.; Carra G.; Morotti A.; Tenace V.; Rapelli S.; Sainas S.; Pippione A.C.; Giorgis M.; Boschi D.; Lolli M.L.; Cilloni D.; Cignetti A.; Saglio G.; Circosta P.
Hydroxyazoles as acid isosteres and their drug design applications—Part 1: Monocyclic systems
2021-01-01 Sainas S.; Pippione A.C.; Boschi D.; Lolli M.L.
AKR1C3 is a biomarker and druggable target for oropharyngeal tumors
2021-01-01 Peraldo-Neia C.; Ostano P.; Mello-Grand M.; Guana F.; Gregnanin I.; Boschi D.; Oliaro-Bosso S.; Pippione A.C.; Carenzo A.; De Cecco L.; Cavalieri S.; Micali A.; Perrone F.; Averono G.; Bagnasacco P.; Dosdegani R.; Masini L.; Krengli M.; Aluffi-Valletti P.; Valente G.; Chiorino G.
Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors
2021-01-01 Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
New inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3) based on benzoisoxazole scaffold and their potential application in cancer
2021-01-01 Mannella, Iole, Vigato, Chiara, Pasha, Rabia; Pippione Agnese Chiara, Sainas, Stefano, Oliaro Bosso Simonetta; Rolando, Barbara; Kovachka, Sandra, Spyrakis, Francesca; Boschi, Donatella, Lolli. Marco Lucio
The inhibition of human DHODH by M433 leads to differentiation and apoptosis in acute myeloid leukemia
2021-01-01 Sainas Stefano, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Gotti Stefano, Saglio Giuseppe., Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
Inibitori della diidroorotato deidrogenasi umana (hDHODH) per l'uso come antivirali
2020-01-01 Boschi Donatella, Giorgis Marta, Lolli Marco Lucio, Saglio Giuseppe, Martinelli Giovanni
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3)
2019-01-01 Chiara Vigato, Agnese Chiara Pippione, Sandra Kovachka, Francesca Spyrakis, Martina Daga, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi
Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3)
2019-01-01 Chiara Vigato, Agnese Chiara Pippione, Sandra Kovachka, Francesca Spyrakis, Martina Daga, Simonetta Oliaro Bosso, Marco Lucio Lolli, Donatella Boschi
Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3
2019-01-01 Lolli, Marco L; Carnovale, Irene M; Pippione, Agnese C; Wahlgren, Weixiao Y; Bonanni, Davide; Marini, Elisabetta; Zonari, Daniele; Gallicchio, Margherita; Boscaro, Valentina; Goyal, Parveen; Friemann, Rosmarie; Rolando, Barbara; Bagnati, Renzo; Adinolfi, Salvatore; Oliaro-Bosso, Simonetta; Boschi, Donatella
Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
2019-01-01 Santos A.R.N.; Sheldrake H.M.; Ibrahim A.I.M.; Danta C.C.; Bonanni D.; Daga M.; Oliaro-Bosso S.; Boschi D.; Lolli M.L.; Pors K.
Synthesis of [18F]Brequinar as PET Imaging probes for human dihydroorotate dehydrogenase
2019-01-01 Elena Martino, Stefano Sainas, Agnese C. Pippione, Donatella Boschi, Yu-Shin Ding, Marco L. Lolli.
Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia
2019-01-01 Gaidano, Valentina; Circosta, Paola; Cignetti, Alessandro; Houshmand, Mohammad; Vitale, Nicoletta; Sainas, Stefano; Pippione, Agnese; Marraudino, Marilena; Bonaldo, Brigitta; Giorgis, Marta; Boschi, Donatella; Lolli, Marco Lucio; Saglio, Giuseppe
Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres
2019-01-01 Sainas, Stefano; Pippione, Agnese C.; Giraudo, Alessandro; Martina, Katia; Bosca, Federica; Rolando, Barbara; Barge, Alessandro; Ducime, Alex; Federico, Antonella; Grossert, Stuart J.; White, Robert L.; Boschi, Donatella; Lolli, Marco L.
NOVEL HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS AND THEIR USE IN TARGETING ONCOLOGICAL DISEASES SENSITIVE TO PYRIMIDINE STARVATION
2019-01-01 BOSCHI DONATELLA, GIORGIS MARTA, LOLLI MARCO LUCIO, SAGLIO GIUSEPPE, MARTINELLI GIOVANNI
Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors
2019-01-01 Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio
A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors.
2019-01-01 Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli
Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor.
2019-01-01 Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli
Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML)
2019-01-01 Giulia De Simone, Stefano Sainas, Marilena Marraudino, Agnese Chiara Pippione, Brigitta Bonaldo, Alice Passoni, Marta Giorgis, Barbara Rolando, Donatella Boschi, Marco Lucio Lolli
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| The synergism between DHODH inhibitors and dipyridamole leads to metabolic lethality in acute myeloid leukemia | 2021 | Gaidano V.; Houshmand M.; Vitale N.; Carra G.; Morotti A.; Tenace V.; Rapelli S.; Sainas S.; Pippione A.C.; Giorgis M.; Boschi D.; Lolli M.L.; Cilloni D.; Cignetti A.; Saglio G.; Circosta P. | |
| Hydroxyazoles as acid isosteres and their drug design applications—Part 1: Monocyclic systems | 2021 | Sainas S.; Pippione A.C.; Boschi D.; Lolli M.L. | |
| AKR1C3 is a biomarker and druggable target for oropharyngeal tumors | 2021 | Peraldo-Neia C.; Ostano P.; Mello-Grand M.; Guana F.; Gregnanin I.; Boschi D.; Oliaro-Bosso S.; Pippione A.C.; Carenzo A.; De Cecco L.; Cavalieri S.; Micali A.; Perrone F.; Averono G.; Bagnasacco P.; Dosdegani R.; Masini L.; Krengli M.; Aluffi-Valletti P.; Valente G.; Chiorino G. | |
| Hydroxylated heterocycles as a bioisosteric tool to Modulate the carboxylic function into design potent human Dihydroorotate Dehydrogenase inhibitors | 2021 | Stefano Sainas, Paola Circosta, Agnese Chiara Pippione, Mohammad Houshmand, Marta Giorgis, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| New inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3) based on benzoisoxazole scaffold and their potential application in cancer | 2021 | Mannella, Iole, Vigato, Chiara, Pasha, Rabia; Pippione Agnese Chiara, Sainas, Stefano, Oliaro Bosso Simonetta; Rolando, Barbara; Kovachka, Sandra, Spyrakis, Francesca; Boschi, Donatella, Lolli. Marco Lucio | |
| The inhibition of human DHODH by M433 leads to differentiation and apoptosis in acute myeloid leukemia | 2021 | Sainas Stefano, Circosta Paola, Pippione Agnese Chiara, Giorgis Marta, Marraudino Marilena, Houshmand Mohammad, Bonaldo Brigitta, Gaidano Valentina, Cignetti Alessandro, Gotti Stefano, Saglio Giuseppe., Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| Inibitori della diidroorotato deidrogenasi umana (hDHODH) per l'uso come antivirali | 2020 | Boschi Donatella, Giorgis Marta, Lolli Marco Lucio, Saglio Giuseppe, Martinelli Giovanni | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3) | 2019 | Chiara Vigato, Agnese Chiara Pippione, Sandra Kovachka, Francesca Spyrakis, Martina Daga, Simonetta Oliaro-Bosso, Marco Lucio Lolli, Donatella Boschi | |
| Application of an in house bioisosteric approach to the design of innovative inhibitors of aldo-keto reductase 1C3 (AKR1C3) | 2019 | Chiara Vigato, Agnese Chiara Pippione, Sandra Kovachka, Francesca Spyrakis, Martina Daga, Simonetta Oliaro Bosso, Marco Lucio Lolli, Donatella Boschi | |
| Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3 | 2019 | Lolli, Marco L; Carnovale, Irene M; Pippione, Agnese C; Wahlgren, Weixiao Y; Bonanni, Davide; Marini, Elisabetta; Zonari, Daniele; Gallicchio, Margherita; Boscaro, Valentina; Goyal, Parveen; Friemann, Rosmarie; Rolando, Barbara; Bagnati, Renzo; Adinolfi, Salvatore; Oliaro-Bosso, Simonetta; Boschi, Donatella | |
| Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity | 2019 | Santos A.R.N.; Sheldrake H.M.; Ibrahim A.I.M.; Danta C.C.; Bonanni D.; Daga M.; Oliaro-Bosso S.; Boschi D.; Lolli M.L.; Pors K. | |
| Synthesis of [18F]Brequinar as PET Imaging probes for human dihydroorotate dehydrogenase | 2019 | Elena Martino, Stefano Sainas, Agnese C. Pippione, Donatella Boschi, Yu-Shin Ding, Marco L. Lolli. | |
| Meds433, a New Dihydroorotate Dehydrogenase Inhibitor, Induces Apoptosis and Differentiation in Acute Myeloid Leukemia | 2019 | Gaidano, Valentina; Circosta, Paola; Cignetti, Alessandro; Houshmand, Mohammad; Vitale, Nicoletta; Sainas, Stefano; Pippione, Agnese; Marraudino, Marilena; Bonaldo, Brigitta; Giorgis, Marta; Boschi, Donatella; Lolli, Marco Lucio; Saglio, Giuseppe | |
| Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres | 2019 | Sainas, Stefano; Pippione, Agnese C.; Giraudo, Alessandro; Martina, Katia; Bosca, Federica; Rolando, Barbara; Barge, Alessandro; Ducime, Alex; Federico, Antonella; Grossert, Stuart J.; White, Robert L.; Boschi, Donatella; Lolli, Marco L. | |
| NOVEL HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS AND THEIR USE IN TARGETING ONCOLOGICAL DISEASES SENSITIVE TO PYRIMIDINE STARVATION | 2019 | BOSCHI DONATELLA, GIORGIS MARTA, LOLLI MARCO LUCIO, SAGLIO GIUSEPPE, MARTINELLI GIOVANNI | |
| Emerging therapies for acute myeloid leukaemia using hDHODH inhibitors | 2019 | Sainas Stefano, Pippione Agnese Chiara, Bonanni Davide, Giorgis Marta, Lupino Elisa, Circosta Paola, Gaidano Valentina, Cignetti Alessandro, Piccinini Marco, Saglio Giuseppe, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco Lucio | |
| A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors. | 2019 | Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Marilena Marraudino, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Marco Lucio Lolli | |
| Improvement of in vivo pharmacokinetic profile of M433, a potent and innovative hDHODH inhibitor. | 2019 | Marta Alberti, Stefano Sainas, Agnese Chiara Pippione, Davide Bonanni, Marta Giorgis, Paola Circosta, Valentina Gaidano, Alessandro Cignetti, Giuseppe Saglio, Donatella Boschi, Marco Lucio Lolli | |
| Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML) | 2019 | Giulia De Simone, Stefano Sainas, Marilena Marraudino, Agnese Chiara Pippione, Brigitta Bonaldo, Alice Passoni, Marta Giorgis, Barbara Rolando, Donatella Boschi, Marco Lucio Lolli |
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