The invention relates to compounds of formulae (I) and (II) which are novel inhibitors of human dihydroorotate dehydrogenase (hDHODH), pharmaceutical compositions containing the aforementioned inhibitors as well as their use in the treatment of TUMOR diseases related, in particular acute myelogenous leukemia (AML), triple- negative breast cancer, PTEN-mutant tumors, and KRAS-driven tumors

NOVEL HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS AND THEIR USE IN TARGETING ONCOLOGICAL DISEASES SENSITIVE TO PYRIMIDINE STARVATION

BOSCHI DONATELLA;GIORGIS MARTA;LOLLI MARCO LUCIO;SAGLIO GIUSEPPE;
2019-01-01

Abstract

The invention relates to compounds of formulae (I) and (II) which are novel inhibitors of human dihydroorotate dehydrogenase (hDHODH), pharmaceutical compositions containing the aforementioned inhibitors as well as their use in the treatment of TUMOR diseases related, in particular acute myelogenous leukemia (AML), triple- negative breast cancer, PTEN-mutant tumors, and KRAS-driven tumors
2019
WO2019/234186 A1
BOSCHI DONATELLA, GIORGIS MARTA, LOLLI MARCO LUCIO, MARTINELLI GIOVANNI, SAGLIO GIUSEPPE
https://worldwide.espacenet.com/patent/search/family/063080415/publication/WO2019234186A1?q=WO2019/234186 A1&called_by=epo.org
Bioisosterism, Dihydroorotate Dehydrogenase (DHODH) inhibitors, Leflunomide, Brequinar, Acute myeloid leukemia (AML), myeloid differentiation
BOSCHI DONATELLA, GIORGIS MARTA, LOLLI MARCO LUCIO, SAGLIO GIUSEPPE, MARTINELLI GIOVANNI
File in questo prodotto:
File Dimensione Formato  
Testo pubblicato Boschi et al. PC1679EC @E0121198.pdf

Accesso aperto

Descrizione: pdf DEL BREVETTO PUBBLICATO
Tipo di file: PDF EDITORIALE
Dimensione 3.03 MB
Formato Adobe PDF
3.03 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1725760
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact