The invention relates to compounds of formulae (I) and (II) which are novel inhibitors of human dihydroorotate dehydrogenase (hDHODH), pharmaceutical compositions containing the aforementioned inhibitors as well as their use in the treatment of TUMOR diseases related, in particular acute myelogenous leukemia (AML), triple- negative breast cancer, PTEN-mutant tumors, and KRAS-driven tumors
NOVEL HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS AND THEIR USE IN TARGETING ONCOLOGICAL DISEASES SENSITIVE TO PYRIMIDINE STARVATION
BOSCHI DONATELLA;GIORGIS MARTA;LOLLI MARCO LUCIO;SAGLIO GIUSEPPE;
2019-01-01
Abstract
The invention relates to compounds of formulae (I) and (II) which are novel inhibitors of human dihydroorotate dehydrogenase (hDHODH), pharmaceutical compositions containing the aforementioned inhibitors as well as their use in the treatment of TUMOR diseases related, in particular acute myelogenous leukemia (AML), triple- negative breast cancer, PTEN-mutant tumors, and KRAS-driven tumors
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