CIRAOLO, Elisa
CIRAOLO, Elisa
BIOTECNOLOGIE MOLECOLARI E SCIENZE PER LA SALUTE
Crossroads of PI3K and Rac pathways
2015-01-01 Campa, Carlo C; Ciraolo, Elisa; Ghigo, Alessandra; Germena, Giulia; Hirsch, Emilio
Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits
2016-01-01 Zamboni, Valentina; Armentano, Maria; Saró, Gabriella; Ciraolo, Elisa; Ghigo, Alessandra; Germena, Giulia; Umbach, Alessandro; Valnegri, Pamela; Passafaro, Maria; Carabelli, Valentina; Gavello, Daniela; Bianchi, Veronica; D'Adamo, Patrizia; De Curtis, Ivan; El-Assawi, Nadia; Mauro, Alessandro; Priano, Lorenzo; Ferri, Nicola; Hirsch, Emilio; Merlo, Giorgio R.
Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility
2010-01-01 Elisa Ciraolo; Fulvio Morello; Robin M. Hobbs; Frieder Wolf; Romina Marone; Manuela Iezzi; Xiaoyun Lu; Giulio Mengozzi; Fiorella Altruda; Giovanni Sorba; Kaomei Guan; Pier Paolo Pandolfi; Matthias P. Wymann; Emilio Hirsch
Genetic deletion and pharmacological inhibition of PI3K γ reduces neutrophilic airway inflammation and lung damage in mice with cystic fibrosis-like lung disease
2015-01-01 Galluzzo, Maria; Ciraolo, Elisa; Lucattelli, Monica; Hoxha, Eriola; Ulrich, Martina; Campa, Carlo Cosimo; Lungarella, Giuseppe; Doring, Gerd; Zhou-Suckow, Zhe; Mall, Marcus; Hirsch, Emilio; De Rose, Virginia
Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM-and integrin-mediated signaling in platelets
2009-01-01 Canobbio I; Stefanini L; Cipolla L; Ciraolo E; Gruppi C; Balduini C; Hirsch E; Torti M
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors.
2011-01-01 Guasconi M; Lu X; Massarotti A; Caldarelli A; Ciraolo E; Tron GC; Hirsch E; Sorba G; Pirali T
Hyper-activation of the Rho-GTPase Rac1 via disruption of ArhGAP15 results in reduced architectural and functional complexity
2015-01-01 Merlo, Giorgio R.; Armentano, Maria; Zamboni, Valentina; Sarò, Gabriella; Berto, Gaia; Ciraolo, Elisa; Ghigo, Alessandra; Passafaro, Maria; Carabelli, Valentina; Gavello, Daniela; El-Assawi, Nadia; Mauro, Alessandro; Priano, Lorenzo; Hirsch, Emilio
Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics
2018-01-01 Zamboni, Valentina; Armentano, Maria; Berto, Gaia; Ciraolo, Elisa; Ghigo, Alessandra; Garzotto, Donatella; Umbach, Alessandro; Dicunto, Ferdinando; Parmigiani, Elena; Boido, Marina; Vercelli, Alessandro; El-Assawy, Nadia; Mauro, Alessandro; Priano, Lorenzo; Ponzoni, Luisa; Murru, Luca; Passafaro, Maria; Hirsch, Emilio*; Merlo, Giorgio R.
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs
2017-01-01 Pirali, Tracey; Ciraolo, Elisa; Aprile, Silvio; Massarotti, Alberto; Berndt, Alex; Griglio, Alessia; Serafini, Marta; Mercalli, Valentina; Landoni, Clarissa; Campa, Carlo Cosimo; Margaria, Jean Piero; Silva, Rangel L.; Grosa, Giorgio; Sorba, Giovanni; Williams, Roger; Hirsch, Emilio; Tron, Gian Cesare
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
2018-01-01 Campa, Carlo C.; Silva, Rangel L.; Margaria, Jean P.; Pirali, Tracey; Mattos, Matheus S.; Kraemer, Lucas R.; Reis, Diego C.; Grosa, Giorgio; Copperi, Francesca; Dalmarco, Eduardo M.; Lima-Júnior, Roberto C. P.; Aprile, Silvio; Sala, Valentina; Dal Bello, Federica; Prado, Douglas Silva; Alves-Filho, Jose Carlos; Medana, Claudio; Cassali, Geovanni D.; Tron, Gian Cesare; Teixeira, Mauro M.; Ciraolo, Elisa; Russo, Remo C.; Hirsch, Emilio
Inhibitors of Phosphatidylinositol 3-Kinases, compositions and uses thereof
2010-01-01 Giovanni SORBA; Gian Cesare TRON; Tracey PIRALI; Ubaldina GALLI; Alberto MASSAROTTI; Emilio HIRSCH; Elisa CIRAOLO
Measuring PI3K lipid kinase activity.
2012-01-01 Ciraolo E;Perino A;Hirsch E
Methods to measure the enzymatic activity of PI3Ks.
2014-01-01 Ciraolo E;Gulluni F;Hirsch E
Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function
2017-01-01 Gulluni, Federico; Martini, Miriam; De Santis, Maria Chiara; Campa, Carlo Cosimo; Ghigo, Alessandra; Margaria, Jean Piero; Ciraolo, Elisa; Franco, Irene; Ala, Ugo; Annaratone, Laura; Disalvatore, Davide; Bertalot, Giovanni; Viale, Giuseppe; Noatynska, Anna; Compagno, Mara; Sigismund, Sara; Montemurro, Filippo; Thelen, Marcus; Fan, Fan; Meraldi, Patrick; Marchiò, Caterina; Pece, Salvatore; Sapino, Anna; Chiarle, Roberto; Di Fiore, Pier Paolo; Hirsch, Emilio
Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits
2018-01-01 Duarte, Larissa Jeremias; Chaves, Vitor Clasen; Nascimento, Marcus Vinicius Pereira dos Santos; Calvete, Eunice; Li, Mingchuan; Ciraolo, Elisa; Ghigo, Alessandra; Hirsch, Emilio; Simões, Claudia Maria Oliveira; Reginatto, Flávio Henrique; Dalmarco, Eduardo M.*
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma
2007-01-01 COSTA C; BARBERIS L; AMBROGIO C; MANAZZA AD; PATRUCCO E; AZZOLINO O; NEILSEN PO; CIRAOLO E; ALTRUDA F; PRESTWICH GD; CHIARLE R; WYMANN M; RIDLEY A; HIRSCH E
PHOSPHOINOSITIDE 3 KINASE BETA ATTENUATES INFLAMMATION AND FIBROSIS IN A BLEOMYCIN MODEL OF ACUTE LUNG INJURY
2009-01-01 Fanelli V; Ciraolo E; Bosco M; Delsedime L; Mensa A; Martin EL; Del sorbo L; Assenzio B; Campanari ML; Hirsch E; Ranieri VM
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development
2008-01-01 Ciraolo E; Iezzi M; Marone R; Marengo S; Curcio C; Costa C; Azzolino O; Gonella C; Rubinetto C; Wu H; Dastrù W; Martin EL; Silengo L; Altruda F; Turco E; Lanzetti L; Musiani P; Rückle T; Rommel C; Backer JM; Forni G; Wymann MP; Hirsch E
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling
2007-01-01 E. HIRSCH; C. COSTA; E. CIRAOLO
PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function.
2014-01-01 Franco I;Gulluni F;Campa CC;Costa C;Margaria JP;Ciraolo E;Martini M;Monteyne D;De Luca E;Germena G;Posor Y;Maffucci T;Marengo S;Haucke V;Falasca M;Perez-Morga D;Boletta A;Merlo GR;Hirsch E
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Crossroads of PI3K and Rac pathways | 2015 | Campa, Carlo C; Ciraolo, Elisa; Ghigo, Alessandra; Germena, Giulia; Hirsch, Emilio | |
| Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits | 2016 | Zamboni, Valentina; Armentano, Maria; Saró, Gabriella; Ciraolo, Elisa; Ghigo, Alessandra; Germena, Giulia; Umbach, Alessandro; Valnegri, Pamela; Passafaro, Maria; Carabelli, Valentina; Gavello, Daniela; Bianchi, Veronica; D'Adamo, Patrizia; De Curtis, Ivan; El-Assawi, Nadia; Mauro, Alessandro; Priano, Lorenzo; Ferri, Nicola; Hirsch, Emilio; Merlo, Giorgio R. | |
| Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility | 2010 | Elisa Ciraolo; Fulvio Morello; Robin M. Hobbs; Frieder Wolf; Romina Marone; Manuela Iezzi; Xiaoyun Lu; Giulio Mengozzi; Fiorella Altruda; Giovanni Sorba; Kaomei Guan; Pier Paolo Pandolfi; Matthias P. Wymann; Emilio Hirsch | |
| Genetic deletion and pharmacological inhibition of PI3K γ reduces neutrophilic airway inflammation and lung damage in mice with cystic fibrosis-like lung disease | 2015 | Galluzzo, Maria; Ciraolo, Elisa; Lucattelli, Monica; Hoxha, Eriola; Ulrich, Martina; Campa, Carlo Cosimo; Lungarella, Giuseppe; Doring, Gerd; Zhou-Suckow, Zhe; Mall, Marcus; Hirsch, Emilio; De Rose, Virginia | |
| Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM-and integrin-mediated signaling in platelets | 2009 | Canobbio I; Stefanini L; Cipolla L; Ciraolo E; Gruppi C; Balduini C; Hirsch E; Torti M | |
| Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors. | 2011 | Guasconi M; Lu X; Massarotti A; Caldarelli A; Ciraolo E; Tron GC; Hirsch E; Sorba G; Pirali T | |
| Hyper-activation of the Rho-GTPase Rac1 via disruption of ArhGAP15 results in reduced architectural and functional complexity | 2015 | Merlo, Giorgio R.; Armentano, Maria; Zamboni, Valentina; Sarò, Gabriella; Berto, Gaia; Ciraolo, Elisa; Ghigo, Alessandra; Passafaro, Maria; Carabelli, Valentina; Gavello, Daniela; El-Assawi, Nadia; Mauro, Alessandro; Priano, Lorenzo; Hirsch, Emilio | |
| Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics | 2018 | Zamboni, Valentina; Armentano, Maria; Berto, Gaia; Ciraolo, Elisa; Ghigo, Alessandra; Garzotto, Donatella; Umbach, Alessandro; Dicunto, Ferdinando; Parmigiani, Elena; Boido, Marina; Vercelli, Alessandro; El-Assawy, Nadia; Mauro, Alessandro; Priano, Lorenzo; Ponzoni, Luisa; Murru, Luca; Passafaro, Maria; Hirsch, Emilio*; Merlo, Giorgio R. | |
| Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs | 2017 | Pirali, Tracey; Ciraolo, Elisa; Aprile, Silvio; Massarotti, Alberto; Berndt, Alex; Griglio, Alessia; Serafini, Marta; Mercalli, Valentina; Landoni, Clarissa; Campa, Carlo Cosimo; Margaria, Jean Piero; Silva, Rangel L.; Grosa, Giorgio; Sorba, Giovanni; Williams, Roger; Hirsch, Emilio; Tron, Gian Cesare | |
| Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis | 2018 | Campa, Carlo C.; Silva, Rangel L.; Margaria, Jean P.; Pirali, Tracey; Mattos, Matheus S.; Kraemer, Lucas R.; Reis, Diego C.; Grosa, Giorgio; Copperi, Francesca; Dalmarco, Eduardo M.; Lima-Júnior, Roberto C. P.; Aprile, Silvio; Sala, Valentina; Dal Bello, Federica; Prado, Douglas Silva; Alves-Filho, Jose Carlos; Medana, Claudio; Cassali, Geovanni D.; Tron, Gian Cesare; Teixeira, Mauro M.; Ciraolo, Elisa; Russo, Remo C.; Hirsch, Emilio | |
| Inhibitors of Phosphatidylinositol 3-Kinases, compositions and uses thereof | 2010 | Giovanni SORBA; Gian Cesare TRON; Tracey PIRALI; Ubaldina GALLI; Alberto MASSAROTTI; Emilio HIRSCH; Elisa CIRAOLO | |
| Measuring PI3K lipid kinase activity. | 2012 | Ciraolo E;Perino A;Hirsch E | |
| Methods to measure the enzymatic activity of PI3Ks. | 2014 | Ciraolo E;Gulluni F;Hirsch E | |
| Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function | 2017 | Gulluni, Federico; Martini, Miriam; De Santis, Maria Chiara; Campa, Carlo Cosimo; Ghigo, Alessandra; Margaria, Jean Piero; Ciraolo, Elisa; Franco, Irene; Ala, Ugo; Annaratone, Laura; Disalvatore, Davide; Bertalot, Giovanni; Viale, Giuseppe; Noatynska, Anna; Compagno, Mara; Sigismund, Sara; Montemurro, Filippo; Thelen, Marcus; Fan, Fan; Meraldi, Patrick; Marchiò, Caterina; Pece, Salvatore; Sapino, Anna; Chiarle, Roberto; Di Fiore, Pier Paolo; Hirsch, Emilio | |
| Molecular mechanism of action of Pelargonidin-3-O-glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits | 2018 | Duarte, Larissa Jeremias; Chaves, Vitor Clasen; Nascimento, Marcus Vinicius Pereira dos Santos; Calvete, Eunice; Li, Mingchuan; Ciraolo, Elisa; Ghigo, Alessandra; Hirsch, Emilio; Simões, Claudia Maria Oliveira; Reginatto, Flávio Henrique; Dalmarco, Eduardo M.* | |
| Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma | 2007 | COSTA C; BARBERIS L; AMBROGIO C; MANAZZA AD; PATRUCCO E; AZZOLINO O; NEILSEN PO; CIRAOLO E; ALTRUDA F; PRESTWICH GD; CHIARLE R; WYMANN M; RIDLEY A; HIRSCH E | |
| PHOSPHOINOSITIDE 3 KINASE BETA ATTENUATES INFLAMMATION AND FIBROSIS IN A BLEOMYCIN MODEL OF ACUTE LUNG INJURY | 2009 | Fanelli V; Ciraolo E; Bosco M; Delsedime L; Mensa A; Martin EL; Del sorbo L; Assenzio B; Campanari ML; Hirsch E; Ranieri VM | |
| Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development | 2008 | Ciraolo E; Iezzi M; Marone R; Marengo S; Curcio C; Costa C; Azzolino O; Gonella C; Rubinetto C; Wu H; Dastrù W; Martin EL; Silengo L; Altruda F; Turco E; Lanzetti L; Musiani P; Rückle T; Rommel C; Backer JM; Forni G; Wymann MP; Hirsch E | |
| Phosphoinositide 3-kinases as a common platform for multi-hormone signaling | 2007 | E. HIRSCH; C. COSTA; E. CIRAOLO | |
| PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function. | 2014 | Franco I;Gulluni F;Campa CC;Costa C;Margaria JP;Ciraolo E;Martini M;Monteyne D;De Luca E;Germena G;Posor Y;Maffucci T;Marengo S;Haucke V;Falasca M;Perez-Morga D;Boletta A;Merlo GR;Hirsch E |