OBJECTIVE: Aim of this study was to further strengthen the association between sleep disorders and migraine. BACKGROUND: An association between primary headaches and sleep disorders has long been recognized. Recently, several studies reported a significant association between restless legs syndrome (RLS) and migraine. DESIGN/METHODS: 136 migraine patients, 102 females (75%) and 34 males ((25%), mean age 53,52 (SD 12,0), 52,8 (SD11,7 in females) and 65,6 (SD 12,8)in males, referring to the outpatients clinic of the Headache Centre of the University of Turin, were enrolled in the study. Migraine diagnosis was made according to ICDH II (2004). Clinical characteristics of migraine, MIDAS questionnaire, subjective evaluation of headache intensity, number of days with migraine in the last 3 months and quantification of the burden of work/social impairment were collected. Anxiety and depression were also evaluated, as well as daylife habits. In collaboration with the Sleep Disorders Centre of the University of Turin, sleep habits and characteristics were collected from each patient, using Pittsburgh Sleep Quality Index (PSQI), Berlin Questionnaire, Epworth Sleepiness Scale (ESS), Restless Legs Syndrome Scale (RLSS). Statistical analysis of data was performed using SPSS 17. RESULTS: The prevalence of RLS in migraine patients resulted 32.4%, significantly higher in comparison with the prevalence of disease in general population. Moreover, a statistically significant association has been found between RLS and migraine severity. CONCLUSIONS: Our data further support the association between migraine and RLS, and suggest a strict relationship between migraine severity and the development of RLS. Additional studies are needed in order to investigate the neurobiological basis of this phenomenon.
Migraine and Restless Legs Syndrome: Further Investigating the Link
DE MARTINO, Paola;PEILA, ELENA;RAINERO, Innocenzo;PINESSI, Lorenzo;CICOLIN, Alessandro
2012-01-01
Abstract
OBJECTIVE: Aim of this study was to further strengthen the association between sleep disorders and migraine. BACKGROUND: An association between primary headaches and sleep disorders has long been recognized. Recently, several studies reported a significant association between restless legs syndrome (RLS) and migraine. DESIGN/METHODS: 136 migraine patients, 102 females (75%) and 34 males ((25%), mean age 53,52 (SD 12,0), 52,8 (SD11,7 in females) and 65,6 (SD 12,8)in males, referring to the outpatients clinic of the Headache Centre of the University of Turin, were enrolled in the study. Migraine diagnosis was made according to ICDH II (2004). Clinical characteristics of migraine, MIDAS questionnaire, subjective evaluation of headache intensity, number of days with migraine in the last 3 months and quantification of the burden of work/social impairment were collected. Anxiety and depression were also evaluated, as well as daylife habits. In collaboration with the Sleep Disorders Centre of the University of Turin, sleep habits and characteristics were collected from each patient, using Pittsburgh Sleep Quality Index (PSQI), Berlin Questionnaire, Epworth Sleepiness Scale (ESS), Restless Legs Syndrome Scale (RLSS). Statistical analysis of data was performed using SPSS 17. RESULTS: The prevalence of RLS in migraine patients resulted 32.4%, significantly higher in comparison with the prevalence of disease in general population. Moreover, a statistically significant association has been found between RLS and migraine severity. CONCLUSIONS: Our data further support the association between migraine and RLS, and suggest a strict relationship between migraine severity and the development of RLS. Additional studies are needed in order to investigate the neurobiological basis of this phenomenon.
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