A serie of 27 N-benzoyl amino acid derivatives were synthesized according to three different approaches (A, B and C moiety), and their ability to inhibit DNMT-dependent total DNA methylation was explored.

Synthesis of Small Molecules as Potential DNA Methylation Modulators

GARELLA, Davide;BRASCHI, ALESSANDRA MARIA;COCCO, MATTIA;GIORGIS, Marta;COSTALE, Annalisa;BERTINARIA, Massimo
2015-01-01

Abstract

A serie of 27 N-benzoyl amino acid derivatives were synthesized according to three different approaches (A, B and C moiety), and their ability to inhibit DNMT-dependent total DNA methylation was explored.
2015
XXIII National Meeting in Medicinal Chemistry - 9th Young Medicinal Chemists Symposium NPCF9
Fisciano - Salerno
06 - 09/09/2015
9th Meeting, Nuove Prospettive in Chimica Farmaceutica
9
"-"
120
120
DNA methylation; Epigenetics; DNMT inhibitors; Structure-Activity Relationships
Garella, Davide; Braschi, Alessandra Maria; Cocco, Mattia; Giorgis, Marta; Costale, Annalisa; Stilo, Antonella Di; Atlante, Sandra; Gaetano, Carlo; Be...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1550951
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