Autism spectrum disorder (ASD) affects up to 1 in 59 individuals1. Genome-wide association and large-scale sequencing studies strongly implicate both common variants2–4 and rare de novo variants5–10 in ASD. Recessive mutations have also been implicated11–14 but their contribution remains less well defined. Here we demonstrate an excess of biallelic lossof-function and damaging missense mutations in a large ASD cohort, corresponding to approximately 5% of total cases, including 10% of females, consistent with a female protective effect. We document biallelic disruption of known or emerging recessive neurodevelopmental genes (CA2, DDHD1, NSUN2, PAH, RARB, ROGDI, SLC1A1, USH2A) as well as other genes not previously implicated in ASD including FEV (FEV transcription factor, ETS family member), which encodes a key regulator of the serotonergic circuitry. Our data refine estimates of the contribution of recessive mutation to ASD and suggest new paths for illuminating previously unknown biological pathways responsible for this condition.

Recessive gene disruptions in autism spectrum disorder

Brusco A.;Ferrero G. B.;Giorgio E.;Riberi E.;
2019

Abstract

Autism spectrum disorder (ASD) affects up to 1 in 59 individuals1. Genome-wide association and large-scale sequencing studies strongly implicate both common variants2–4 and rare de novo variants5–10 in ASD. Recessive mutations have also been implicated11–14 but their contribution remains less well defined. Here we demonstrate an excess of biallelic lossof-function and damaging missense mutations in a large ASD cohort, corresponding to approximately 5% of total cases, including 10% of females, consistent with a female protective effect. We document biallelic disruption of known or emerging recessive neurodevelopmental genes (CA2, DDHD1, NSUN2, PAH, RARB, ROGDI, SLC1A1, USH2A) as well as other genes not previously implicated in ASD including FEV (FEV transcription factor, ETS family member), which encodes a key regulator of the serotonergic circuitry. Our data refine estimates of the contribution of recessive mutation to ASD and suggest new paths for illuminating previously unknown biological pathways responsible for this condition.
NATURE GENETICS
51
7
1092
1098
http://www.nature.com/ng/index.html
Autism Spectrum Disorder; Case-Control Studies; Cohort Studies; Female; Genes, Recessive; Genome, Human; Humans; Male; Whole Exome Sequencing; Allelic Imbalance; Genetic Predisposition to Disease; Mutation, Missense
Doan R.N.; Lim E.T.; De Rubeis S.; Betancur C.; Cutler D.J.; Chiocchetti A.G.; Overman L.M.; Soucy A.; Goetze S.; ASC consortium; Brusco A.; Curró A.; Fallerini C.; Lopergolo D.; Lintas C.; Domenici E.; Dalla Bernardina B.; Ferrero G.B.; Giorgio E.; Trabetti E.; Renieri A.; Riberi E.; Freitag C.M.; Daly M.J.; Walsh C.A.; Buxbaum J.D.; Yu T.W.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1725347
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