Impact on the Health-Promoting Potential of Cranberries for Food Applications Through Soilless Cultivation Practices in Piemonte Region (Italy): A Sustainable Opportunity for Nutraceutical Production

Cranberry (Vaccinium macrocarpon Aiton), a traditional berry crop cultivated in North America, is appreciated for its high amounts of bioactive compounds and polyphenols. The exploration of its cultivation in different geographic areas may support crop diversification and sustainable production of fruits and derived products rich in health-promoting molecules. The present research evaluated the antioxidant capacity, phytochemical profile, and nutritive composition of the 'Pilgrim' cranberry cultivar grown in soilless conditions in Northwestern Italy (Bra, Piemonte Region), compared to a reference sample from North America (Canada). Physical-chemical parameters such as weight, fruit size, titratable acidity, and total soluble solids were considered. Additionally, anthocyanins, total phenolics, antioxidant capacity, and proanthocyanidins (PACs) were evaluated using spectrophotometric protocols. Chromatographic techniques (HPLC-MS/MS and HPLC-DAD) were used for detailed profiling of phenolic acids, flavonoids, vitamin C, sugars, organic acids, and PAC types (A- and B-type dimers and trimers). The results highlighted that Italian-grown cranberry fruits, although smaller, showed significantly higher levels of PACs (+61%), anthocyanins (+58%), total polyphenolic compounds (+48%), and antioxidant capacity than North American ones. This may be due to the inhibition of fruit growth by elevated temperatures, resulting in a better synthesis of antioxidants and bioactive compounds. This study may promote the cultivation of cranberries in different climatic regions, as a complementary strategy to international imports, and improve the production of new food applications with a high content of health-promoting molecules. Additionally, the production of antioxidants in plants under challenging conditions may potentially stimulate further studies to address climate change and investigate crop diversification.