This study shows a new "one-stage" surgical procedure for cartilage repair combining in situ minced autolologous cartilage fragments, as source of viable cells and chondrogenic stimuli, with a resorbable scaffold composed of fibrin glue and high-molecular-weight hyaluronic acid derivative.In vivo in 24 adult rabbits, repair process was evaluated with morphological and hystological analysis. This study suggests that autologous cartilage fragments embedded in HA/fibrin resorbable scaffold provide a viable sourgce of cells and chondrogenic stimuli for a one-stage non-cultured based repair of full-thickness articular cartilage repair.

One stage osteochondral repair with cartilage Fragments in HA/fibrin scaffoid: in vitro and in vivo animal model.

CASTOLDI, Filippo;ROSSI, Roberto;MAIELLO, Alessio;PARISI, Silvia;TARONE, Guido;PEIRONE, Bruno;MAUTHE DEGERFELD, Mitzy
2009

Abstract

This study shows a new "one-stage" surgical procedure for cartilage repair combining in situ minced autolologous cartilage fragments, as source of viable cells and chondrogenic stimuli, with a resorbable scaffold composed of fibrin glue and high-molecular-weight hyaluronic acid derivative.In vivo in 24 adult rabbits, repair process was evaluated with morphological and hystological analysis. This study suggests that autologous cartilage fragments embedded in HA/fibrin resorbable scaffold provide a viable sourgce of cells and chondrogenic stimuli for a one-stage non-cultured based repair of full-thickness articular cartilage repair.
10th EFORT Congress
Vienna (Austria)
3-6 june 2009
Atti 10th EFORT Congress
EFORT
X
P2053
P2053
Orthopedics; One-stage osteochondral repair; Rabbit animal model; Hybrid scaffold
Marmotti A.; Castoldi F.; Rossi R.; Bruzzone M.; Maiello A.; Parisi S.; Tarone G.; Peirone B.; Mauthe Degerfeld M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/95253
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