One stage osteochondral repair with cartilage Fragments in HA/fibrin scaffoid: in vitro and in vivo animal model.

This study shows a new "one-stage" surgical procedure for cartilage repair combining in situ minced autolologous cartilage fragments, as source of viable cells and chondrogenic stimuli, with a resorbable scaffold composed of fibrin glue and high-molecular-weight hyaluronic acid derivative.In vivo in 24 adult rabbits, repair process was evaluated with morphological and hystological analysis. This study suggests that autologous cartilage fragments embedded in HA/fibrin resorbable scaffold provide a viable sourgce of cells and chondrogenic stimuli for a one-stage non-cultured based repair of full-thickness articular cartilage repair.